A novel oxidative deoximation method was developed in this article. Compared with the reported organoselenium-catalyzed oxidative deoximation reaction, this reaction employed N-hydroxyphthalimide (NHPI) as the co-catalyst, so that the oxidative deoximation reaction could utilize air as oxidant in the green DMC solvent under mild reaction conditions. Control experiments and X-ray photoelectron spectroscopy (XPS) analysis results indicated that NHPI was essential for activating the catalytic organoselenium species. It could accelerate the activation of molecular oxygen in air to promote the reaction process. The reaction can avoid metal residues in product and is of potential application values in pharmaceutical industry due to the transition metal-free process.

本文开发了一种新的氧化脱肟方法。与报道的有机硒催化氧化脱肟反应相比，该反应采用N-羟基邻苯二甲酰亚胺（NHPI）作为助催化剂，因此氧化脱肟反应可以在绿色DMC溶剂中在温和的反应条件下利用空气作为氧化剂。对照实验和 X 射线光电子能谱 (XPS) 分析结果表明，NHPI 对于激活催化有机硒物质至关重要。可加速空气中分子氧的活化，促进反应进程。该反应可以避免产品中的金属残留，由于是无过渡金属工艺，因此在制药工业中具有潜在的应用价值。