We have developed a novel bioactive hybrid metallic implant that integrates the beneficial characteristics of a permanent matrix and a biodegradable substance. Such a combination may generate a material system that evolves into a porous structure within weeks to months following implantation and can be used to form strong interfacial bonding and osseointegration for orthopedic and dental applications. Presently, traditional technologies such as casting, powder metallurgy and plastic forming have limited ability to produce the complex bioactive implant structures that are required in practical applications. The present study aimed to develop an innovative bioactive TiMg (BTiMg) hybrid system using a Ti-lattice (Ti-6Al-4 V) produced by an additive manufacturing (AM) process, in combination with a new Mg-based alloy (Mg-2.4%Nd −0.6%Y -0.3%Zr) as a biodegradable filling material. We evaluated the in-vitro behavior of the BTiMg system in a simulated physiological environment, along with cytotoxicity assessment. The microstructure was evaluated by scanning electron microscopy and X-ray diffraction, mechanical properties were examined in terms of compressive strength, environmental performance analysis was conducted by electrochemical testing using potentiodynamic polarization and impedance spectroscopy (EIS), and cytotoxicity characteristics were assessed by indirect cell viability analysis. The results demonstrated the feasibility to produce geometrically complex implants by AM technology, as well as the strength and non-cytotoxic effects of the BTiMg system. Benefits included a relatively high ultimate compressive strength (UCS) and a high yield point (YP), along with an adequate cell viability response in the range between 70 and 120%.

我们开发了一种新型的生物活性混合金属植入物，它结合了永久基质和可生物降解物质的有益特性。这种组合可以产生一种材料系统，该系统在植入后数周至数月内演变成多孔结构，并可用于形成用于整形外科和牙科应用的强界面粘合和骨整合。目前，铸造、粉末冶金和塑性成型等传统技术生产实际应用所需的复杂生物活性植入物结构的能力有限。本研究旨在开发一种创新的生物活性钛使用通过增材制造 (AM) 工艺生产的 Ti-晶格 (Ti-6Al-4 V) 的 Mg (BTiMg) 混合系统，结合新的镁基合金 (Mg-2.4%Nd -0.6%Y -0.3 %Zr) 作为可生物降解的填充材料。我们评估了 BTiMg 系统在模拟生理环境中的体外行为以及细胞毒性评估。通过扫描电子显微镜和 X 射线衍射评估微观结构，从抗压强度方面检查机械性能，通过使用动电位极化和阻抗谱 (EIS) 的电化学测试进行环境性能分析，并通过间接电池评估细胞毒性特性。可行性分析。结果证明了通过 AM 技术生产几何复杂植入物的可行性，以及 BTiMg 系统的强度和非细胞毒性作用。优点包括相对较高的极限抗压强度 (UCS) 和高屈服点 (YP)，以及在 70% 到 120% 之间的足够的细胞活力响应。