The present study aimed to verify the effects of resistance training (RT) and successive detraining on body composition, muscle strength and lipid profile as primary outcome, and the oxidative stress and inflammatory markers as second outcome of postmenopausal Breast Cancer (BC) survivors undergoing tamoxifen (TA). Fourteen postmenopausal BC survivors underwent 12 weeks of resistance exercise training and subsequently 12 weeks of detraining. Anthropometric parameters, lipid profile, muscle strength, inflammatory cytokines and the oxidative stress markers, were assessed before, after the training period and after detraining period. One-way ANOVA showed that fat mass decrease (39.4 ± 6.9 to 37.7 ± 6.8%) and free-fat mass increase (39.3 ± 4.9 to 40.3 ± 5.6%) after RT. Muscle strength increased in response to training but decreased after the detraining period. Triglycerides (156 ± 45 to 123 ± 43 mg/dL) and total cholesterol (202 ± 13 to 186 ± 16 mg/dL) decreased after the RT and HDL-cholesterol (47 ± 9 to 56 ± 9 mg/dL) increased after RT and remained higher (53 ± 10 mg/dL) than after detraining. IL-6 increases (24.65 ± 10.85 to 41.42 ± 22.88 pg/mL) and IL-17 (2.42 ± 0.32 to 1.69 ± 0.19 pg/mL), TBARS (1.91 ± 0.19 to 1.03 ± 0.1 μmol/L), SOD (24.65 ± 10.85 to 41.42 ± 22.88 U/gHb) and Catalase activity (445.9 ± 113.0 to 345.8 ± 81.7 k/gHb·s) reduced after RT and remained lower after detraining. Resistance exercise training improves health markers of BC survivors undergoing TA and detraining are not sufficient to reverse the positive effects in oxidative stress markers.

中文翻译：

---

运动训练和停止训练对接受他莫昔芬治疗的乳腺癌幸存者的身体成分、肌肉力量和脂质、炎症和氧化标志物的影响


本研究旨在验证阻力训练 (RT) 和连续停止训练对接受他莫昔芬的绝经后乳腺癌 (BC) 幸存者的主要结果是身体成分、肌肉力量和血脂状况的影响，以及作为第二个结果的氧化应激和炎症标志物的影响（助教）。 14 名绝经后 BC 幸存者接受了 12 周的阻力运动训练，随后进行了 12 周的停止训练。在训练之前、之后和训练结束之后评估人体测量参数、血脂、肌肉力量、炎症细胞因子和氧化应激标记物。单向方差分析显示，RT 后脂肪量减少（39.4 ± 6.9 至 37.7 ± 6.8%），游离脂肪量增加（39.3 ± 4.9 至 40.3 ± 5.6%）。肌肉力量随着训练而增加，但在训练结束后却下降。 RT 后甘油三酯（156 ± 45 至 123 ± 43 mg/dL）和总胆固醇（202 ± 13 至 186 ± 16 mg/dL）降低，HDL 胆固醇（47 ± 9 至 56 ± 9 mg/dL）升高RT 仍高于训练后 (53 ± 10 mg/dL)。 IL-6 增加（24.65 ± 10.85 至 41.42 ± 22.88 pg/mL），IL-17 增加（2.42 ± 0.32 至 1.69 ± 0.19 pg/mL），TBARS（1.91 ± 0.19 至 1.03 ± 0.1 µmol/L），SOD（24.65） ± 10.85 至 41.42 ± 22.88 U/gHb）和过氧化氢酶活性（445.9 ± 113.0 至 345.8 ± 81.7 k/gHb·s）在 RT 后降低，并在去训练后保持较低水平。抗阻运动训练可改善接受 TA 的 BC 幸存者的健康指标，而停止训练不足以逆转氧化应激指标的积极影响。