Anchorage-Dependent Living Supramolecular Self-Assembly of Polymeric Micelles,Journal of the American Chemical Society

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Anchorage-Dependent Living Supramolecular Self-Assembly of Polymeric Micelles
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-09-02 , DOI: 10.1021/jacs.1c06020
Zhengmin Tang ₁ , Liang Gao ₁ , Jiaping Lin ₁ , Chunhua Cai ₁ , Yuan Yao ₁ , Gerald Guerin ₁ , Xiaohui Tian ₁ , Shaoliang Lin ₁

Affiliation

Anchorage-dependent contact-inhibited growth usually refers to on-surface cell proliferation inhibited by the proximity of other cells. This phenomenon, prominent in nature, has yet to be achieved with polymeric micelles. Here, we report the control living supra-macromolecular self-assembly of elongated micelles with a liquid crystalline core onto a hydrophobic substrate via the synergetic interactions between the substrate and aggregates dispersed in solution. In this system, seed formation is a transient phenomenon induced by the adsorption and rearrangement of the core-swollen aggregates. The seeds then trigger the growth of elongated micelles onto the substrate in a living controllable manner until the contact with the substrate is disrupted. Brownian dynamic simulations show that this unique behavior is due to the fusion of the aggregates onto both ends of the anchored seeds. More important, the micelle length can be tuned by varying the substrate hydrophobicity, a key step toward the fabrication of intricate structures.

中文翻译：

聚合物胶束的锚定依赖性活性超分子自组装

锚定依赖性接触抑制生长通常是指表面细胞增殖受其他细胞的接近抑制。这种在自然界中很突出的现象尚未通过聚合物胶束实现。在这里，我们报告了通过基材和分散在溶液中的聚集体之间的协同相互作用，将具有液晶核的细长胶束的控制活超大分子自组装到疏水基材上。在该系统中，种子形成是由核心溶胀聚集体的吸附和重排引起的瞬态现象。然后，种子以活性可控的方式触发细长胶束在基材上的生长，直到与基材的接触被破坏。布朗动力学模拟表明，这种独特的行为是由于聚合体融合到锚定种子的两端。更重要的是，胶束长度可以通过改变基材疏水性来调节，这是制造复杂结构的关键一步。

更新日期：2021-09-15

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