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SARS-CoV-2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability
Journal of Chemical Information and Modeling ( IF 5.6 ) Pub Date : 2021-09-02 , DOI: 10.1021/acs.jcim.1c00990 David Shorthouse 1 , Benjamin A Hall 1
Journal of Chemical Information and Modeling ( IF 5.6 ) Pub Date : 2021-09-02 , DOI: 10.1021/acs.jcim.1c00990 David Shorthouse 1 , Benjamin A Hall 1
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The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic. We show that mutations in the spike protein of SARS-CoV-2 are selecting for amino acid changes that result in a more thermodynamically stable protein than expected from background. We suggest that the computationally efficient analysis of mutational stability may aid in early screening of variants.
中文翻译：
SARS-CoV-2 变体正在选择增加蛋白质稳定性的刺突蛋白突变
刺突蛋白突变的 SARS-CoV-2 变体的出现是人们关注疫苗功效和控制大流行的主要原因。我们表明，SARS-CoV-2 刺突蛋白的突变正在选择氨基酸变化，从而产生比背景预期更热力学稳定的蛋白质。我们建议突变稳定性的计算有效分析可能有助于早期筛选变体。
更新日期：2021-09-27
中文翻译：
SARS-CoV-2 变体正在选择增加蛋白质稳定性的刺突蛋白突变
刺突蛋白突变的 SARS-CoV-2 变体的出现是人们关注疫苗功效和控制大流行的主要原因。我们表明，SARS-CoV-2 刺突蛋白的突变正在选择氨基酸变化，从而产生比背景预期更热力学稳定的蛋白质。我们建议突变稳定性的计算有效分析可能有助于早期筛选变体。
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