The complex steps leading to the central nervous system (CNS) inflammation and the progress to neuroinflammatory and neurodegenerative disorders have opened up new research and intervention avenues. This review focuses on the therapeutic targeting of the VLA-4 integrin to discuss the clear-cut effect on immune cell trafficking into brain tissues. Besides, we explore the possibility that blocking VLA-4 may have a relevant impact on nonmigratory activities of immune cells, such as antigen presentation and T-cell differentiation, during the neuroinflammatory process. Lastly, the recent refinement of computational techniques is highlighted as a way to increase specificity and to reduce the detrimental side effects of VLA-4 immunotherapies aiming at developing better clinical interventions.
Neuroimmunomodulation

中文翻译：

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VLA-4 作为调节神经炎症性疾病的中心靶点

导致中枢神经系统 (CNS) 炎症的复杂步骤以及神经炎症和神经退行性疾病的进展开辟了新的研究和干预途径。本综述侧重于 VLA-4 整合素的治疗靶向，以讨论对免疫细胞转运到脑组织的明确影响。此外，我们探索了在神经炎症过程中阻断 VLA-4 可能对免疫细胞的非迁移活动（如抗原呈递和 T 细胞分化）产生相关影响的可能性。最后，最近对计算技术的改进被强调为一种提高特异性和减少 VLA-4 免疫疗法有害副作用的方法，旨在开发更好的临床干预措施。
神经免疫调节