Photobiomodulation (PBM) is attracting increased attention in the fields of dermatology and cosmetics. PBM with a variety of light parameters has been used widely in skin care, but can cause certain types of unwanted cells to proliferate in the skin; this can lead to skin tumors, such as papillomas and cancers. We constructed a mouse model of human skin tumors using DMBA as an initiator and TPA as a promoter, and confirmed that LEDs with a wavelength of 642 nm (red light) increased tumor size, epidermal thickness, and systemic proinflammatory cytokine levels. These results indicated that skin tumor cell proliferation may result from the use of 642 nm LEDs, suggesting the need for regulation of skin care based on LED light therapy.

中文翻译：

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使用波长为 642 nm 的 LED 处理可增强小鼠模型中的皮肤肿瘤增殖

光生物调节 (PBM) 在皮肤病学和化妆品领域越来越受到关注。具有多种光参数的 PBM 已广泛用于皮肤护理，但会导致某些类型的不需要的细胞在皮肤中增殖；这会导致皮肤肿瘤，如乳头状瘤和癌症。我们使用 DMBA 作为引发剂和 TPA 作为启动子构建了人类皮肤肿瘤的小鼠模型，并证实波长为 642 nm（红光）的 LED 增加了肿瘤大小、表皮厚度和全身促炎细胞因子水平。这些结果表明，使用 642 nm LED 可能会导致皮肤肿瘤细胞增殖，这表明需要基于 LED 光疗法来调节皮肤护理。