Abstract: Esophageal cancer is one of the most common malignancy in China with high mortality. Understanding pathogenesis and identifying early diagnosis biomarkers can significantly improve the prognosis of patients with esophageal cancer. Exosomes are small vesicular structures containing a variety of components (including DNA, RNA, and proteins) mediating cell-to-cell material exchange and signal communication. Growing evidences have shown that exosomes and its components are involved in growth, metastasis and angiogenesis in cancer, and could also be used as diagnostic and prognostic markers. In this review, we summarized recent progress to elucidate the significance of exosomes in the esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression. We also discuss the utility of exosomes as diagnostic and prognostic biomarkers and therapeutic tool in esophageal cancer.

Keywords: exosome, esophageal cancer, biomarkers, liquid biopsy, prognosis


中文翻译：

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外泌体在食管癌发病机制、诊断和治疗中的意义

摘要：食管癌是我国最常见的恶性肿瘤之一，死亡率高。了解发病机制和识别早期诊断生物标志物可以显着改善食管癌患者的预后。外泌体是包含多种成分（包括 DNA、RNA 和蛋白质）的小囊泡结构，可介导细胞间物质交换和信号通信。越来越多的证据表明，外泌体及其成分参与癌症的生长、转移和血管生成，也可用作诊断和预后标志物。在这篇综述中，我们总结了最近的进展，以阐明外泌体在食管癌进展、微环境重塑、治疗抵抗和免疫抑制中的重要性。

关键词：外泌体，食管癌，生物标志物，液体活检，预后