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Frequency and Predictors of Early Seizures Following First Acute Stroke: Data from a University Hospital in South India
Neurology India ( IF 0.9 ) Pub Date : 2021-07-01 , DOI: 10.4103/0028-3886.325345 Surya P Turaga 1 , Rangineni L Chaithanya 1 , Abhijeet K Kohat 1 , Suvarna Alladi 1 , Subhash Kaul 1
Background: Stroke is a common neurological condition, and post-stroke seizures are known to occur. Early seizures may suggest the severity of insult and may have an effect on the outcome. There are conflicting results on the frequency of early seizures, and studies from India are scarce.
Aim: To study the frequency and predictors of early seizures following the first acute stroke, both arterial and venous stroke, as well as to assess their effect on clinical outcome.
Patients and Methods: This is a hospital-based, prospective, observational study conducted among 279 eligible consecutive patients admitted in the Neurology department with first acute stroke, including venous stroke. The demographic data, clinical history, risk factors, examination, and all other relevant investigations are done. Early seizures occurring within 7 days of the acute stroke are identified and correlated to various risk factors.
Results: Out of the 279 patients enrolled in the study, ischemic stroke (IS) (62.4%) was the most common stroke subtype, followed by hemorrhagic stroke (HS) (20.4%), cerebral sinus venous thrombosis (CSVT) (15.8%), and IS with hemorrhagic transformation (ISH) (1.8%). Thirty-three patients (11.8%) had early seizures, among them CSVT 18 (40.9%) had the highest frequency followed by ISH 1 (20%), HS 5 (8.7%), and IS 9 (5.2%).
Conclusions: The frequency of early onset post-stroke seizures is 11.8%, with most of them occurring within 24 hours. Venous stroke, large lesion, cortical location, supratentorial location, hypercoaguable states, and hyperhomocysteinemia are independent predictors. Duration of hospital stay is increased in patients with early seizures, however, they did not influence the in-hospital mortality.
中文翻译：
第一次急性中风后早期癫痫发作的频率和预测因素：来自南印度大学医院的数据
背景：中风是一种常见的神经系统疾病，已知会发生中风后癫痫发作。早期癫痫发作可能表明侮辱的严重程度，并可能对结果产生影响。关于早期癫痫发作的频率存在相互矛盾的结果，而且来自印度的研究很少。
目的：研究第一次急性卒中后早期癫痫发作的频率和预测因子，包括动脉和静脉卒中，并评估它们对临床结果的影响。
患者和方法：这是一项以医院为基础的前瞻性观察性研究，对 279 名在神经科收治的首次急性卒中（包括静脉性卒中）的符合条件的连续患者进行了研究。完成人口统计数据、临床病史、危险因素、检查和所有其他相关调查。确定急性中风后 7 天内发生的早期癫痫发作，并将其与各种危险因素相关联。
结果：在参加该研究的 279 名患者中，缺血性中风 (IS) (62.4%) 是最常见的中风亚型，其次是出血性中风 (HS) (20.4%)、脑窦静脉血栓形成 (CSVT) (15.8%)、和出血转化 (ISH) 的 IS (1.8%)。33 例患者 (11.8%) 出现早期癫痫发作，其中 CSVT 18 例 (40.9%) 发生频率最高，其次是 ISH 1 (20%)、HS 5 (8.7%) 和 IS 9 (5.2%)。
结论：早发型脑卒中后癫痫发作的频率为 11.8%，其中大部分发生在 24 小时内。静脉中风、大损伤、皮层位置、幕上位置、高凝状态和高同型半胱氨酸血症是独立的预测因子。早期癫痫发作患者的住院时间会增加，但不会影响院内死亡率。
更新日期：2021-09-02
Neurology India ( IF 0.9 ) Pub Date : 2021-07-01 , DOI: 10.4103/0028-3886.325345 Surya P Turaga 1 , Rangineni L Chaithanya 1 , Abhijeet K Kohat 1 , Suvarna Alladi 1 , Subhash Kaul 1
Affiliation
Background: Stroke is a common neurological condition, and post-stroke seizures are known to occur. Early seizures may suggest the severity of insult and may have an effect on the outcome. There are conflicting results on the frequency of early seizures, and studies from India are scarce.
Aim: To study the frequency and predictors of early seizures following the first acute stroke, both arterial and venous stroke, as well as to assess their effect on clinical outcome.
Patients and Methods: This is a hospital-based, prospective, observational study conducted among 279 eligible consecutive patients admitted in the Neurology department with first acute stroke, including venous stroke. The demographic data, clinical history, risk factors, examination, and all other relevant investigations are done. Early seizures occurring within 7 days of the acute stroke are identified and correlated to various risk factors.
Results: Out of the 279 patients enrolled in the study, ischemic stroke (IS) (62.4%) was the most common stroke subtype, followed by hemorrhagic stroke (HS) (20.4%), cerebral sinus venous thrombosis (CSVT) (15.8%), and IS with hemorrhagic transformation (ISH) (1.8%). Thirty-three patients (11.8%) had early seizures, among them CSVT 18 (40.9%) had the highest frequency followed by ISH 1 (20%), HS 5 (8.7%), and IS 9 (5.2%).
Conclusions: The frequency of early onset post-stroke seizures is 11.8%, with most of them occurring within 24 hours. Venous stroke, large lesion, cortical location, supratentorial location, hypercoaguable states, and hyperhomocysteinemia are independent predictors. Duration of hospital stay is increased in patients with early seizures, however, they did not influence the in-hospital mortality.
中文翻译：
第一次急性中风后早期癫痫发作的频率和预测因素：来自南印度大学医院的数据
背景：中风是一种常见的神经系统疾病，已知会发生中风后癫痫发作。早期癫痫发作可能表明侮辱的严重程度，并可能对结果产生影响。关于早期癫痫发作的频率存在相互矛盾的结果，而且来自印度的研究很少。
目的：研究第一次急性卒中后早期癫痫发作的频率和预测因子，包括动脉和静脉卒中，并评估它们对临床结果的影响。
患者和方法：这是一项以医院为基础的前瞻性观察性研究，对 279 名在神经科收治的首次急性卒中（包括静脉性卒中）的符合条件的连续患者进行了研究。完成人口统计数据、临床病史、危险因素、检查和所有其他相关调查。确定急性中风后 7 天内发生的早期癫痫发作，并将其与各种危险因素相关联。
结果：在参加该研究的 279 名患者中，缺血性中风 (IS) (62.4%) 是最常见的中风亚型，其次是出血性中风 (HS) (20.4%)、脑窦静脉血栓形成 (CSVT) (15.8%)、和出血转化 (ISH) 的 IS (1.8%)。33 例患者 (11.8%) 出现早期癫痫发作，其中 CSVT 18 例 (40.9%) 发生频率最高，其次是 ISH 1 (20%)、HS 5 (8.7%) 和 IS 9 (5.2%)。
结论：早发型脑卒中后癫痫发作的频率为 11.8%，其中大部分发生在 24 小时内。静脉中风、大损伤、皮层位置、幕上位置、高凝状态和高同型半胱氨酸血症是独立的预测因子。早期癫痫发作患者的住院时间会增加，但不会影响院内死亡率。
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