Iodine has long been recognized as an essential micronutrient for maternal thyroid function, as well as fetal growth and development during pregnancy. The current study aimed to evaluate thyroid hormone status, urinary iodine concentration (UIC), thyroid volume, and nodularity in pregnant women, throughout trimesters, in a borderline iodine sufficient, urban area with mandatory table salt iodization. Two-hundred-sixty-five pregnant women ranging from 17 to 45 years participated in this prospective longitudinal study. Thyroid function tests, thyroid volume, nodule growth, and UIC were recorded throughout the first, second, and third trimesters with no intervention. Median UIC was 96, 78, and 60 µg/L in the first, second, and third trimester of pregnancy, respectively (p < 0.001). Mean TSH values increased significantly (i.e. 0.65 mIU/ml, 1.1 mIU/ml, and 1.3 mIU/ml in the first, second, and third trimesters, respectively) (p < 0.001). Mean ± s.d. thyroid volume was significantly higher in the third trimester (14.72 ± 6.8 ml) compared with the first trimester (13.69 ± 5.31 ml) (p < 0.001). An intensifying iodine deficiency (ID) was reported throughout trimesters in this cohort of pregnant women from Ankara. A significant percentage of pregnant women from a borderline iodine sufficient, urban area in Turkey were iodine deficient during all trimesters, and the deficiency increased throughout the pregnancy. Pregnant women should receive iodine supplementation, besides consuming iodized salt in borderline iodine sufficient areas.

中文翻译：

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土耳其安卡拉一个碘充足的边缘城市地区，整个孕期碘缺乏症加剧。

碘长期以来被认为是孕妇甲状腺功能以及怀孕期间胎儿生长发育的必需微量营养素。目前的研究旨在评估孕妇的甲状腺激素状态、尿碘浓度 (UIC)、甲状腺体积和结节性，在整个孕期，在临界碘充足的城市地区，强制食盐加碘。265 名 17 至 45 岁的孕妇参加了这项前瞻性纵向研究。甲状腺功能测试、甲状腺体积、结节生长和 UIC 在整个妊娠早期、中期和晚期都被记录，没有干预。妊娠早期、中期和晚期的 UIC 中位数分别为 96、78 和 60 µg/L (p < 0.001)。平均 TSH 值显着增加（即 0.65 mIU/ml，1. 妊娠早期、中期和晚期分别为 1 mIU/ml 和 1.3 mIU/ml）（p < 0.001）。与妊娠早期 (13.69 ± 5.31 ml) 相比，妊娠晚期的平均 ± sd 甲状腺体积 (14.72 ± 6.8 ml) 显着更高 (p < 0.001)。据报道，这组来自安卡拉的孕妇在整个孕期都出现了加剧的碘缺乏症 (ID)。土耳其城市地区碘充足的临界孕妇中有很大一部分在整个孕期都缺碘，并且在整个怀孕期间缺碘情况有所增加。孕妇除了在临界碘充足地区食用碘盐外，还应补充碘。与妊娠早期 (13.69 ± 5.31 ml) 相比，妊娠晚期 (14.72 ± 6.8 ml) 的甲状腺体积显着增加 (p < 0.001)。据报道，这组来自安卡拉的孕妇在整个孕期都出现了加剧的碘缺乏症 (ID)。土耳其城市地区碘充足的临界孕妇中有很大一部分在整个孕期都缺碘，并且在整个怀孕期间缺碘情况有所增加。孕妇除了在临界碘充足地区食用碘盐外，还应补充碘。与妊娠早期 (13.69 ± 5.31 ml) 相比，妊娠晚期 (14.72 ± 6.8 ml) 的甲状腺体积显着增加 (p < 0.001)。据报道，这组来自安卡拉的孕妇在整个孕期都出现了加剧的碘缺乏症 (ID)。土耳其城市地区碘充足的临界孕妇中有很大一部分在整个孕期都缺碘，并且在整个怀孕期间缺碘情况有所增加。孕妇除了在临界碘充足地区食用碘盐外，还应补充碘。土耳其城市地区碘充足的临界孕妇中有很大一部分在整个孕期都缺碘，并且在整个怀孕期间缺碘情况有所增加。孕妇除了在临界碘充足地区食用碘盐外，还应补充碘。土耳其城市地区碘充足的临界孕妇中有很大一部分在整个孕期都缺碘，并且在整个怀孕期间缺碘情况有所增加。孕妇除了在临界碘充足地区食用碘盐外，还应补充碘。