INTRODUCTION There are no available low-burden, point-of-care tests to diagnose, grade, and predict hepatic encephalopathy (HE). METHODS We evaluated speech as a biomarker of HE in 76 English-speaking adults with cirrhosis. RESULTS Three speech features significantly correlated with the following neuropsychiatric scores: speech rate, word duration, and use of particles. Patients with low neuropsychiatric scores had slower speech (22 words/min, P = 0.01), longer word duration (0.09 seconds/word, P = 0.01), and used fewer particles (0.85% fewer, P = 0.01). Patients with a history of overt HE had slower speech (23 words/min, P = 0.005) and longer word duration (0.09 seconds/word, P = 0.005). DISCUSSION HE is associated with slower speech.

中文翻译：

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肝性脑病与客观评估时言语缓慢有关。

引言 目前还没有可用的低负担即时检测来诊断、分级和预测肝性脑病 (HE)。方法 我们对 76 名讲英语的肝硬化成人患者的言语作为 HE 的生物标志物进行了评估。结果 三个言语特征与以下神经精神评分显着相关：语速、单词持续时间和粒子的使用。神经精神评分较低的患者言语速度较慢（22 个词/分钟，P = 0.01），词持续时间较长（0.09 秒/词，P = 0.01），并且使用的粒子较少（减少 0.85%，P = 0.01）。有明显 HE 病史的患者言语速度较慢（23 个词/分钟，P = 0.005），词持续时间较长（0.09 秒/词，P = 0.005）。讨论 HE 与语速较慢有关。