Climatic conditions raise new concerns about the potential impact of heat on the absorption and kinetics of certain chemicals. The impact of 3 temperatures (21, 25 and 30 °C WBGT) on the toxicokinetics of toluene and acetone was therefore evaluated in five human subjects during controlled exposures in an inhalation chamber. Biological samples were collected and analyzed by GC–MS/MS. Increases between 4 and 85 % were observed for solvents concentrations in blood (30 vs 21 °C) while decreases in urine samples for acetone and o-cresol were measured at the end of the exposure period (4 h). Mean blood concentrations at 4 h are well correlated with temperature. Results suggest an increased absorption and/or a decreased elimination of volatile chemicals in the presence of heat. Higher increases of blood chemical concentrations were observed in heavier individuals. Further studies should include physiologically based toxicokinetic models to help in better understanding the mechanisms involved and their respective contribution.

气候条件引发了人们对热量对某些化学品的吸收和动力学的潜在影响的新担忧。因此，在吸入室中受控暴露期间，在 5 名人类受试者中评估了 3 种温度（21、25 和 30 °C WBGT）对甲苯和丙酮的毒代动力学的影响。收集生物样品并通过 GC-MS/MS 进行分析。观察到血液中溶剂浓度增加了 4% 到 85%（30 与 21 °C），而在暴露期结束时（4 小时）测量到丙酮和邻甲酚的尿样减少。4 小时的平均血液浓度与温度密切相关。结果表明，在存在热量的情况下，挥发性化学物质的吸收增加和/或消除减少。在较重的个体中观察到血液化学浓度的更高增加。进一步的研究应包括基于生理的毒代动力学模型，以帮助更好地了解所涉及的机制及其各自的贡献。