Macrophage-hitchhiking supramolecular aggregates of CuS nanoparticles for enhanced tumor deposition and photothermal therapy,Nanoscale Horizons

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Macrophage-hitchhiking supramolecular aggregates of CuS nanoparticles for enhanced tumor deposition and photothermal therapy
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2021-09-01 , DOI: 10.1039/d1nh00291k
Junyan Li ₁ , Qian Cheng ₁ , Ludan Yue ₁ , Cheng Gao ₁ , Jianwen Wei ₁ , Yuanfu Ding ₁ , Yitao Wang ₁ , Ying Zheng _{1,

2} , Ruibing Wang _{1,

2}

Affiliation

In this design, small CuS nanoparticles (NPs) were intracellularly self-assembled into large supramolecular aggregates via host–guest interactions between sequentially internalized β-cyclodextrin-capped CuS NPs and ferrocene-capped CuS NPs inside macrophages, thus the efflux of CuS NPs was significantly inhibited during the macrophage-hitchhiking delivery. Biodistribution studies in mice confirmed the dramatically enhanced deposition of CuS NPs in the tumor tissue of mice injected with macrophages carrying intracellular CuS aggregates, in comparison to that of mice treated with macrophages carrying CuS NPs. In response to the inflammatory tumor microenvironment, the oxidation of ferrocene would dissociate the β-cyclodextrin–ferrocene host–guest pair, driving disassembly of the CuS aggregates and release of small CuS NPs for deep tissue penetration and enhanced photothermal therapy. This precisely controlled intracellular self-assembly and disassembly of the nanomedicine inside macrophages provides a novel cell-hitchhiking delivery strategy that not only minimizes premature leakage of the nanomedicine but also greatly improves the delivery efficiency and tumor penetration for safe, effective tumor therapy.

中文翻译：

CuS纳米颗粒的巨噬细胞搭便车超分子聚集体用于增强肿瘤沉积和光热治疗

在此设计中，小的CuS纳米颗粒（NP）为在细胞内自组装成较大的超分子聚集物通过巨噬细胞内依次内化的β-环糊精封端的CuS NPs和二茂铁封端的CuS NPs之间的主客体相互作用，因此在巨噬细胞搭便车过程中CuS NPs的外流受到显着抑制。小鼠的生物分布研究证实，与用携带 CuS NPs 的巨噬细胞治疗的小鼠相比，注射了携带细胞内 CuS 聚集体的巨噬细胞的小鼠肿瘤组织中 CuS NPs 的沉积显着增强。为了响应炎症性肿瘤微环境，二茂铁的氧化会解离 β-环糊精-二茂铁主客体对，驱动 CuS 聚集体的分解和小 CuS NPs 的释放，用于深层组织渗透和增强光热治疗。

更新日期：2021-09-01

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