The development of novel luminescent materials with multi-stimuli responsive and multi-functional properties is required. In this work, we designed and synthesized a novel AIE-based fluorenone derivative, MBPF. The donor–acceptor–donor (D–A–D) structure promoted the intermolecular hydrogen bonding capacity of the exposed oxygen atom in fluorenone. MBPF displayed three different aggregation morphologies: an amorphous floccule Y-MBPF with yellow-green luminescence, a block crystal O-MBPF with orange luminescence, and a needlelike crystal R-MBPF with red emission. They all exhibited reversible stimuli-response phase transitions to temperature and shear, accompanied by fluorescence switching. The orange crystal O-MBPF was also sensitive to isotropic hydrostatic pressure with prominent and contrasting luminescent conversion. Furthermore, we prepared MBPF nanocrystallites and encapsulated them with DSPE–PEG and the monoclonal antibody cetuximab (C225) to obtain MBPF-C225 NPs, which were biocompatible and photostable. They could be used for specific cancer cell imaging through receptor-mediated endocytosis.

中文翻译：

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基于AIE的供体-受体-供体芴酮化合物作为多功能发光材料

需要开发具有多刺激响应和多功能特性的新型发光材料。在这项工作中，我们设计并合成了一种新型的基于 AIE 的芴酮衍生物MBPF。供体-受体-供体（D-A-D）结构促进了芴酮中暴露氧原子的分子间氢键能力。MBPF表现出三种不同的聚集形态：具有黄绿色发光的无定形絮凝体Y-MBPF、具有橙色发光的块状晶体O-MBPF和具有红色发光的针状晶体R-MBPF。它们都表现出对温度和剪切的可逆刺激响应相变，伴随着荧光转换。橙色水晶O-MBPF也对各向同性静水压力敏感，具有显着且对比鲜明的发光转换。此外，我们制备了MBPF纳米微晶，并用 DSPE-PEG 和单克隆抗体西妥昔单抗 (C225) 封装它们，以获得生物相容性和光稳定性的MBPF-C225 NP。它们可以通过受体介导的内吞作用用于特定的癌细胞成像。