A series of bioactive glass scaffolds doped with SrO or ZnO (0, 5, and 10 mol%) were synthesized by the foam replica and melting method. The thermodynamic evolution, phase composition, microstructure, ion release, in vitro bioactivity, and oxygen density of the scaffolds were characterized. The proliferation of murine long bone osteocyte Y4 cells was studied by cell culture. The survival rate of the BGs evaluated the antibacterial activity and Escherichia coli strains in co-culture. The results indicated that the process window decreases with the increase of dopants. All the samples have a pore structure size of 200–400 μm. When the scaffolds were immersed in simulated body fluid for 28 days, hydroxyapatite formation was not affected, but the degradation process was retarded. The glass network packing and ionic radii variations of the substitution ions control surface degradation, glass dissolution, and ion release. MTT results revealed that 5Sr-BG had a significant effect on promoting cell proliferation and none of the BGs were cytotoxicity. Sr-BGs and Zn-BGs exhibited significantly inhibited growth against E. coli bacterial strains. Generally, these results showed the 5Sr-BG scaffold with high vitro bioactivity, cell proliferation, and antibacterial property is an important candidate material for bone tissue regeneration and repair.

通过泡沫复制和熔化法合成了一系列掺杂有 SrO 或 ZnO（0、5 和 10 mol%）的生物活性玻璃支架。表征了支架的热力学演变、相组成、微观结构、离子释放、体外生物活性和氧密度。通过细胞培养研究鼠长骨骨细胞 Y4 细胞的增殖。BGs的存活率评价抗菌活性和大肠杆菌共培养菌株。结果表明，工艺窗口随着掺杂物的增加而减小。所有样品的孔结构尺寸为 200-400 μm。当支架在模拟体液中浸泡 28 天时，羟基磷灰石的形成没有受到影响，但降解过程被延缓。取代离子的玻璃网络堆积和离子半径变化控制表面降解、玻璃溶解和离子释放。MTT结果显示，5Sr-BG对促进细胞增殖有显着作用，且均无细胞毒性。Sr-BGs 和 Zn-BGs 表现出对大肠杆菌的显着抑制生长细菌菌株。总体而言，这些结果表明具有高体外生物活性、细胞增殖和抗菌性能的 5Sr-BG 支架是骨组织再生和修复的重要候选材料。