Two new glycosides, periplanosides A (1) and B (2), 3 compounds reported from a natural source for the first time (3 − 5), and 6 known compounds 6 − 11 were isolated from the ethanol extract of Periplaneta americana (Linnaeus). Their structures, including absolute configurations, were unambiguously identified by comprehensive spectroscopic and chemical methods. Compound 3 is a racemate whose enantiomers were purified by chiral high-performance liquid chromatography . The biological evaluation results showed that compound 7 (0 − 20 μM) did not affect the viability of RAW264.7 cells and could effectively inhibit the production of interleukin-6 stimulated by lipopolysaccharide in a concentration-dependent manner, indicating the potential to develop novel agents against inflammation-related diseases.

从美洲大蠊(Linnaeus)的乙醇提取物中分离得到2种新苷A ( 1 ) 和B ( 2 )、3种首次从天然来源报道的化合物( 3  -  5 )和6种已知化合物6  -  11）。它们的结构，包括绝对构型，已通过综合光谱和化学方法明确识别。化合物3为外消旋体，其对映体经手性高效液相色谱纯化。生物学评价结果表明，化合物7 (0 - 20 μM) 不影响 RAW264.7 细胞的活力，并且可以以浓度依赖的方式有效抑制脂多糖刺激的白细胞介素 6 的产生，表明开发针对炎症相关疾病的新型药物的潜力。