Introduction: There are limited reports on the natural history of hen’s egg (HE) allergy (HEA) in children #x3c;6 years. We aimed to investigate the natural history of HEA in children aged 6–12 years and the factors affecting its tolerance acquisition. Methods: Using the database in our hospital, a total of 137 patients diagnosed with a definitive immediate-type reaction to HE when they turned 6 years were enrolled, and the natural course of HEA was prospectively examined until patients turned 12 years. Tolerance was defined as being able to pass an oral food challenge to consume a half or whole heated HE or consume heated HE freely without symptoms. Thirty patients (21.9%) who were enrolled for oral immunotherapy and 21 (15.3%) who discontinued follow-up were considered dropouts. Kaplan-Meier estimation was used to evaluate the rate of tolerance. Results: Fifty-five of the 137 patients (40.1%) had a previous HE anaphylaxis history; 61 (44.5%) patients had acquired tolerance to HE by age 12 years; and 25 (18.2%) continued total or partial HE elimination. The estimated acquired tolerance rates by ages 7, 9, and 12 years were 14.6%, 40.8%, and 60.5%, respectively. A previous history of HE anaphylaxis before 6 years of age, reacting to small amounts of heated HE by 6 years of age, and higher ovomucoid-specific immunoglobulin E values at the same age were associated with persistent HEA. Conclusion: This study provides important insights into the natural course of HEA beyond early childhood, with the acquisition of HE tolerance continuing throughout the duration of the study.
Int Arch Allergy Immunol

中文翻译：

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鸡蛋过敏的自然史：一项针对 6 至 12 岁儿童的前瞻性研究

简介：关于 #x3c;6 岁儿童鸡蛋 (HE) 过敏 (HEA) 自然史的报道有限。我们旨在调查 6-12 岁儿童 HEA 的自然史以及影响其耐受性获得的因素。方法：使用我院的数据库，共纳入 137 名在 6 岁时被诊断为明确的即刻型 HE 反应的患者，并前瞻性检查了 HEA 的自然病程，直至患者 12 岁。耐受性被定义为能够通过口服食物挑战以消耗一半或全部加热的 HE 或无症状地自由消耗加热的 HE。30 名 (21.9%) 参加口服免疫治疗的患者和 21 名 (15.3%) 停止随访的患者被视为退出。Kaplan-Meier 估计用于评估耐受率。结果：137 名患者中有 55 名（40.1%）有既往 HE 过敏史；61 名 (44.5%) 患者在 12 岁时获得了对 HE 的耐受性；和 25 (18.2%) 人继续完全或部分消除 HE。7、9 和 12 岁的估计获得性耐受率分别为 14.6%、40.8% 和 60.5%。6 岁之前有 HE 过敏反应史、6 岁时对少量加热的 HE 有反应以及相同年龄较高的卵类粘蛋白特异性免疫球蛋白 E 值与持续性 HEA 相关。结论：这项研究提供了对儿童早期以外 HEA 的自然过程的重要见解，在整个研究期间持续获得 HEA 耐受性。
Int Arch 过敏免疫