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Ratiometric Detection of Hypochlorous Acid in Brain Tissues of Neuroinflammation and Maternal Immune Activation Models with a Deep-Red/Near-Infrared Emitting Probe
ACS Sensors ( IF 8.2 ) Pub Date : 2021-09-01 , DOI: 10.1021/acssensors.1c00930 Kyeong Hwan Kim 1 , Soo Jeong Kim 2 , Subhankar Singha 3 , Yun Jae Yang 1 , Sang Ki Park 2 , Kyo Han Ahn 1
ACS Sensors ( IF 8.2 ) Pub Date : 2021-09-01 , DOI: 10.1021/acssensors.1c00930 Kyeong Hwan Kim 1 , Soo Jeong Kim 2 , Subhankar Singha 3 , Yun Jae Yang 1 , Sang Ki Park 2 , Kyo Han Ahn 1
Affiliation
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Reactive oxygen species (ROS) produced by an inflammatory response in the brain are associated with various neurological disorders. To investigate ROS-associated neuroinflammatory diseases, fluorescent probes with practicality are in demand. We have investigated hypochlorous acid, an important ROS, in the brain tissues of neuroinflammation and maternal immune activation (MIA) model mice, using a new fluorescent probe. The probe has outstanding features over many known probes, such as providing two bright ratio signals in cells and tissues in deep-red/near-infrared wavelength regions with a large spectral separation, in addition to being strongly fluorescent, photo- and chemo-stable, highly selective and sensitive, fast responding, and biocompatible. We have found that the level of hypochlorous acid in the brain tissue of a neuroinflammatory mouse model was higher (2.7–4.0-fold) compared with that in normal brain tissue. Furthermore, the level of hypochlorous acid in the brain tissue of a MIA mouse model was higher (1.2–1.3-fold) compared with that in the normal brain tissue. The “robust” probe provides a practical tool for studying ROS-associated neurological disorders.
中文翻译：
用深红/近红外发射探针对神经炎症和母体免疫激活模型脑组织中次氯酸的比率检测
大脑炎症反应产生的活性氧 (ROS) 与各种神经系统疾病有关。为了研究 ROS 相关的神经炎症疾病，需要具有实用性的荧光探针。我们使用新的荧光探针研究了神经炎症和母体免疫激活 (MIA) 模型小鼠脑组织中的次氯酸，一种重要的 ROS。与许多已知探针相比，该探针具有突出的特性，例如在深红/近红外波长区域提供两种亮比信号，具有较大的光谱分离度，此外还具有强荧光、光和化学稳定性，高选择性和灵敏性，快速响应和生物相容性。我们发现，与正常脑组织相比，神经炎症小鼠模型脑组织中的次氯酸水平更高（2.7-4.0 倍）。此外，与正常脑组织相比，MIA 小鼠模型脑组织中的次氯酸水平更高（1.2-1.3 倍）。“稳健”探针为研究 ROS 相关神经系统疾病提供了实用工具。
更新日期：2021-09-24
中文翻译：
用深红/近红外发射探针对神经炎症和母体免疫激活模型脑组织中次氯酸的比率检测
大脑炎症反应产生的活性氧 (ROS) 与各种神经系统疾病有关。为了研究 ROS 相关的神经炎症疾病，需要具有实用性的荧光探针。我们使用新的荧光探针研究了神经炎症和母体免疫激活 (MIA) 模型小鼠脑组织中的次氯酸，一种重要的 ROS。与许多已知探针相比，该探针具有突出的特性，例如在深红/近红外波长区域提供两种亮比信号，具有较大的光谱分离度，此外还具有强荧光、光和化学稳定性，高选择性和灵敏性，快速响应和生物相容性。我们发现，与正常脑组织相比，神经炎症小鼠模型脑组织中的次氯酸水平更高（2.7-4.0 倍）。此外，与正常脑组织相比，MIA 小鼠模型脑组织中的次氯酸水平更高（1.2-1.3 倍）。“稳健”探针为研究 ROS 相关神经系统疾病提供了实用工具。
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