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Administration and monitoring of clofazimine for NTM infections in children with and without cystic fibrosis
Journal of Cystic Fibrosis ( IF 5.4 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.jcf.2021.08.010
L H Cameron 1 , C A Peloquin 2 , P Hiatt 3 , M Mann 3 , J R Starke 1 , J Faircloth 4 , J C McNeil 1 , A Patel 3 , F Ruiz 3
Affiliation  

Few studies have evaluated clofazimine (CLOF) drug monitoring and safety in children. We treated 10 children, 8 with CF, for NTM infection with multiple antimicrobials, including CLOF. All had serial blood CLOF concentrations measured and were followed for adverse events. Despite CLOF dose escalation, most children with CF did not reach a target CLOF concentration. Our data suggest that children with CF may require earlier initiation of CLOF at higher doses than is currently recommended.



中文翻译:

氯法齐明在有和没有囊性纤维化的儿童中的 NTM 感染的给药和监测

很少有研究评估氯法齐明 (CLOF) 在儿童中的药物监测和安全性。我们用多种抗菌药物(包括 CLOF)治疗了 10 名儿童(其中 8 名患有 CF)的 NTM 感染。所有人都测量了连续的血液 CLOF 浓度,并跟踪了不良事件。尽管 CLOF 剂量增加,但大多数 CF 儿童并未达到目标 CLOF 浓度。我们的数据表明,患有 CF 的儿童可能需要比目前推荐的更高剂量更早开始 CLOF。

更新日期:2021-09-01
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