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The risk of chronic diseases and congenital malformations during childhood and adolescence after in utero exposure to thiopurines
Alimentary Pharmacology & Therapeutics ( IF 6.6 ) Pub Date : 2021-08-31 , DOI: 10.1111/apt.16578
Line Riis Jølving 1, 2 , Pavithra Laxsen Anru 1 , Jan Nielsen 1, 2 , Sonia Friedman 2, 3 , Bente Mertz Nørgård 1, 2, 3
Affiliation  

Women with autoimmune diseases, particularly inflammatory bowel disease (IBD), often need to continue immunomodulatory therapies during pregnancy. While the evidence of birth and short-term outcomes in children exposed in utero to these medicines is reassuring, long-term safety data are lacking.

中文翻译:

子宫内暴露于硫嘌呤后儿童和青春期慢性病和先天性畸形的风险

患有自身免疫性疾病,尤其是炎症性肠病 (IBD) 的女性在怀孕期间通常需要继续免疫调节治疗。虽然子宫内暴露于这些药物的儿童出生和短期结果的证据令人放心,但缺乏长期安全性数据。
更新日期:2021-09-27
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