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Innate Immunity Protein IFITM3 in Alzheimer's Disease
DNA and Cell Biology ( IF 2.6 ) Pub Date : 2021-11-12 , DOI: 10.1089/dna.2021.0585
Ji-Yeun Hur 1
Affiliation  

Several genes in innate immunity have been implicated in Alzheimer's disease (AD). However, the effect of innate immunity on amyloid β (Aβ) production, which makes amyloid plaques in AD brains, was previously not known. Recently, the antiviral protein interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel γ-secretase modulatory protein for Aβ production. In this review, the mechanisms of how innate immunity modulates Aβ production via IFITM3-γ-secretase complexes and contributes to AD pathogenesis are discussed.

中文翻译:

阿尔茨海默病中的先天免疫蛋白 IFITM3

先天免疫中的几个基因与阿尔茨海默病(AD)有关。然而,先天免疫对淀粉样蛋白 β (Aβ) 产生的影响,在 AD 大脑中形成淀粉样蛋白斑块,以前是未知的。最近,抗病毒蛋白干扰素诱导的跨膜蛋白 3 (IFITM3) 已被鉴定为一种用于 Aβ 产生的新型 γ-分泌酶调节蛋白。在这篇综述中,讨论了先天免疫如何通过 IFITM3-γ-分泌酶复合物调节 Aβ 产生并促进 AD 发病机制。
更新日期:2021-11-13
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