Several genes in innate immunity have been implicated in Alzheimer's disease (AD). However, the effect of innate immunity on amyloid β (Aβ) production, which makes amyloid plaques in AD brains, was previously not known. Recently, the antiviral protein interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel γ-secretase modulatory protein for Aβ production. In this review, the mechanisms of how innate immunity modulates Aβ production via IFITM3-γ-secretase complexes and contributes to AD pathogenesis are discussed.

中文翻译：

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阿尔茨海默病中的先天免疫蛋白 IFITM3

先天免疫中的几个基因与阿尔茨海默病（AD）有关。然而，先天免疫对淀粉样蛋白 β (Aβ) 产生的影响，在 AD 大脑中形成淀粉样蛋白斑块，以前是未知的。最近，抗病毒蛋白干扰素诱导的跨膜蛋白 3 (IFITM3) 已被鉴定为一种用于 Aβ 产生的新型 γ-分泌酶调节蛋白。在这篇综述中，讨论了先天免疫如何通过 IFITM3-γ-分泌酶复合物调节 Aβ 产生并促进 AD 发病机制。