Living with HIV has been proposed as a risk factor for the early development of functional decline. Composite marker tools like the Veterans Aging Cohort Study (VACS) Index, which includes HIV-associated and non-HIV-related markers of disease may better reflect multiorgan system injury and potentially predict functional outcomes. Therefore, the objective of this work is to determine whether higher VACS 2.0 Index scores predicts functional decline among older adults living with HIV (OALWH). Longitudinal study, including 131 adults ages 50 or older who underwent a comprehensive geriatric assessment at baseline and follow-up, at least a year apart. Functional status was determined by the gait speed (seconds for a 4-m distance). Linear regression models were constructed to determine the relationship between VACS 2.0 Index at baseline with gait speed at follow-up adjusted for potential confounders. The median for age was 58.0 years (range 50–84), and 81.7% were male. At baseline, the median VACS 2.0 Index score was 50.4 (interquartile range 42.2–65.3). The adjusted linear regression analysis found that higher baseline VACS 2.0 Index scores were significantly associated with a decline in gait speed (p = .033) at follow-up. The results suggest that the VACS 2.0 Index works as a predictor of functional decline as showed by decline in gait speed and might serve as an easy tool to identify OALWH who might need additional resources or interventions to prevent it.

中文翻译：

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高级退伍军人老龄化队列研究 2.0 指数评分预测感染艾滋病毒的老年人的功能衰退

艾滋病毒感染被认为是功能衰退早期发展的危险因素。复合标记工具，如退伍军人老龄化队列研究 (VACS) 指数，其中包括 HIV 相关和非 HIV 相关的疾病标记，可以更好地反映多器官系统损伤并可能预测功能结果。因此，这项工作的目的是确定较高的 VACS 2.0 指数分数是否预示感染艾滋病毒的老年人 (OALWH) 的功能下降。纵向研究，包括 131 名 50 岁或以上的成年人，他们在基线和随访时进行了全面的老年评估，至少相隔一年。功能状态由步态速度（4 米距离的秒数）决定。构建线性回归模型以确定 VACS 2 之间的关系。0 基线指数，随访时的步态速度针对潜在的混杂因素进行了调整。年龄中位数为 58.0 岁（范围 50-84），81.7% 为男性。在基线时，中位 VACS 2.0 指数得分为 50.4（四分位距为 42.2-65.3）。调整后的线性回归分析发现，较高的基线 VACS 2.0 指数分数与步态速度的下降显着相关。p  = .033) 在随访中。结果表明，VACS 2.0 指数可作为功能下降的预测指标，如步态速度下降所示，并可作为识别可能需要额外资源或干预措施来预防的 OALWH 的简单工具。