Near Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Shijiazhuang City, Hebei Province, China,AIDS Research and Human Retroviruses

当前位置： X-MOL 学术 › AIDS Res. Hum. Retrovir. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Near Full-Length Genomic Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Shijiazhuang City, Hebei Province, China
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2021-12-15 , DOI: 10.1089/aid.2021.0100
Leilei Han _{1,

2} , Hanping Li ₃ , Lijing Wang ₂ , Lei Jia ₃ , Jingwan Han ₃ , Tianyi Li ₃ , Xiaolin Wang ₃ , Yongjian Liu ₃ , Jingyun Li ₃ , Jianhua Lu ₂ , Xiaojing Qu ₂ , Xuhui He ₄ , Haichun Liu ₅ , Lin Li ₃ , Erhei Dai _{1,

2}

Affiliation

Unique recombinant forms (URFs) are more likely developed among HIV-1 infections through men who have sex with men (MSM) because of cocirculation of multiple subtypes. In this study, two novel URFs deriving from two HIV-positive subjects (HB010014, HB010063) were identified in Shijiazhuang, Hebei province, China, and two sequences formed a distinct monophyletic cluster. Further recombination analysis showed that of two new URFs were consisted of circulating recombinant form (CRF)01_AE and CRF07_BC. The subregion phylogenetic analysis indicated that CRF01_AE segments were traced back to cluster 4 of CRF01_AE strains, which were prevalent among HIV-1 infections through MSM in China. New URFs being developing gradually and spreading released that more and more novel recombinant strains of HIV-1 could be developed, which means that the past prevention strategies need to be adjusted.

更新日期：2021-12-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11