There are limiteddata on long-term changes in the gut microbiome after acute lymphoblastic leukemia (ALL) therapy. We compared the gut microbial composition in stool samples of nine survivors of childhood ALL with 10 healthy sibling controls using 16S rRNA gene sequencing. Analysis of beta diversity within family units demonstrated a significant difference in bacterial strains between patients and healthy siblings. A significant difference in alpha diversity between patients and their healthy siblings was noted using Pielou's evenness. The composition of the gut microbiome differs between pediatric ALL survivors and healthy sibling controls for years after completion of therapy.

中文翻译：

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儿童急性淋巴细胞白血病幸存者肠道微生物组的持久变化

关于急性淋巴细胞白血病 (ALL) 治疗后肠道微生物组的长期变化的数据有限。我们使用 16S rRNA 基因测序比较了 9 名儿童 ALL 幸存者与 10 名健康兄弟姐妹的粪便样本中的肠道微生物组成。家庭单位内的β多样性分析表明，患者和健康兄弟姐妹之间的细菌菌株存在显着差异。使用 Pielou 的均匀度注意到患者与其健康兄弟姐妹之间 alpha 多样性的显着差异。在完成治疗后的数年内，儿童 ALL 幸存者和健康兄弟姐妹之间的肠道微生物组组成不同。