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Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-08-31 , DOI: 10.3233/jad-215143
Wenlei Yu 1, 2 , Linjie Lu 1, 2 , Xintong Ji 1, 2 , Qiwei Qian 1, 2 , Xiaohan Lin 1 , Huanhuan Wang 1, 2
Affiliation  

Chronic periodontitis caused by Porphyromonas gingivalis (P. gingivalis) infection generally lasts for a lifetime. The long-term existence and development of P. gingivalis infection gradually aggravate the accumulation of inflammatory signals and toxic substances in the body. Recent evidence has revealed that P. gingivalis infection may be relevant to some central nervous system (CNS) diseases. The current work collects information and tries to explore the possible relationship between P. gingivalis infection and CNS diseases, including the interaction or pathways between peripheral infection and CNS injury, and the underlying neurotoxic mechanisms.

中文翻译:

牙龈卟啉单胞菌牙周感染与中枢神经系统损伤可能关系的研究进展

牙龈卟啉单胞菌(P. gingivalis)感染引起的慢性牙周炎一般会持续一生。牙龈卟啉单胞菌感染的长期存在和发展逐渐加剧了体内炎症信号和有毒物质的积累。最近的证据表明,牙龈卟啉单胞菌感染可能与某些中枢神经系统 (CNS) 疾病有关。目前的工作收集信息并试图探索牙龈卟啉单胞菌感染与中枢神经系统疾病之间可能的关系,包括外周感染与中枢神经系统损伤之间的相互作用或途径,以及潜在的神经毒性机制。
更新日期:2021-09-01
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