Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder,Neurobiology of Stress

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Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder
Neurobiology of Stress ( IF 4.3 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.ynstr.2021.100389
Liat Helpman _{1,

2,

3} , Xi Zhu ₃ , Sigal Zilcha-Mano ₁ , Benjamin Suarez-Jimenez ₄ , Amit Lazarov _{3,

5} , Bret Rutherford ₃ , Yuval Neria ₃

Affiliation

Background

Posttraumatic stress disorder (PTSD) is twice as prevalent among females as compared to males following potentially traumatic events. While there is evidence for aberrant functional connectivity between hubs of the central executive network (CEN), salience network (SN), and the default mode network (DMN) in PTSD, little is known regarding sex-specificity of this connectivity. The current study aims to directly examine sex-specific resting-state functional connectivity (rs-FC) in trauma exposed males and females, with and without PTSD.

Methods

One hundred and seventy-eight individuals underwent functional magnetic resonance imaging (fMRI) at rest, of them 85 females (45 with PTSD) and 93 males (57 with PTSD). We conducted whole-brain seed-based analysis using CEN (lateral prefrontal cortex [lPFC]), SN (anterior cingulate cortex [ACC], insula, amygdala [AMG]), and DMN (medial prefrontal cortex [mPFC], posterior parietal cortex [PCC], and hippocampus [HIP]) hubs as seed regions. Group-by-Sex ANOVA was conducted.

Results

The amygdala-precuneus, ACC-precuneus, and hippocampus-precuneus pathways exhibited significant group-by-sex interaction effects, with females with PTSD consistently differing in connectivity patterns from males with PTSD and from trauma-exposed healthy females.

Conclusions

Sex-specific neural connectivity patterns were found within and between key nodes of the CEN, DMN, and the SN, suggesting opposite patterns of connectivity in PTSD and trauma-exposed controls as a function of sex as a biological variable (SABV). This may point to mechanistic sex differences in adaptation following trauma and may inform differential neural targets for treatment of females and males with PTSD.

中文翻译：

女性与男性在创伤后应激障碍中的静息状态功能连接模式逆转

背景

发生潜在创伤事件后，女性的创伤后应激障碍 (PTSD) 是男性的两倍。虽然有证据表明 PTSD 中的中央执行网络 (CEN)、显着网络 (SN) 和默认模式网络 (DMN) 的枢纽之间存在异常的功能连接，但对于这种连接的性别特异性知之甚少。目前的研究旨在直接检查有和没有 PTSD 的受创伤的男性和女性的性别特异性静息状态功能连接 (rs-FC)。

方法

178 人在休息时接受了功能性磁共振成像 (fMRI)，其中 85 名女性（45 名患有 PTSD）和 93 名男性（57 名患有 PTSD）。我们使用 CEN（外侧前额叶皮层 [lPFC]）、SN（前扣带回皮层 [ACC]、岛叶、杏仁核 [AMG]）和 DMN（内侧前额叶皮层 [mPFC]、后顶叶皮层）进行了基于全脑种子的分析[PCC] 和海马 [HIP]) 枢纽作为种子区域。进行了按性别进行的 ANOVA。