Water-Promoted Reaction of C60Ar5Cl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties,Organic Letters

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Water-Promoted Reaction of C60Ar5Cl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-01 , DOI: 10.1021/acs.orglett.1c02623
Olga A Kraevaya ₁ , Valeriya S Bolshakova _{1,

2} , Alexander S Peregudov ₃ , Alexander V Chernyak ₁ , Nikita A Slesarenko ₁ , Vitaliy Yu Markov ₄ , Natalia S Lukonina ₄ , Vyacheslav M Martynenko ₁ , Ekaterina O Sinegubova ₅ , Alexander F Shestakov _{1,

6} , Vladimir V Zarubaev ₅ , Dominique Schols ₇ , Pavel A Troshin _{1,

8}

Affiliation

Here we report a reaction of the fullerene derivatives C₆₀Ar₅Cl, which enables the substitution of Cl with thiophene residues and the formation of the novel family of C₁-symmetrical C₆₀ fullerene derivatives with six functional addends C₆₀Ar₅Th. The discovered reaction provided a straightforward approach to the synthesis of previously inaccessible multifunctional water-soluble fullerene derivatives, including the compounds with antiviral activity against human immunodeficiency and influenza viruses.

中文翻译：

C60Ar5Cl 化合物与噻吩的水促进反应提供了一系列具有选择性抗病毒特性的多功能富勒烯衍生物

在这里，我们报道了富勒烯衍生物 C ₆₀ Ar ₅ Cl 的反应，该反应能够用噻吩残基取代 Cl 并形成具有六个功能加成 C ₆₀ Ar ₅ Th的新型C ₁ -对称 C _{60富勒烯衍生物家族。}发现的反应为合成以前无法获得的多功能水溶性富勒烯衍生物提供了一种直接的方法，包括对人类免疫缺陷和流感病毒具有抗病毒活性的化合物。

更新日期：2021-09-17

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