Anodal high definition transcranial direct current stimulation (HD-tDCS) targeting the pre-supplementary motor area/dorsal anterior cingulate cortex (pre-SMA/dACC) has recently been shown to improve verbal retrieval deficits in veterans with chronic traumatic brain injury (TBI) (Motes et al., 2020), but predictors of treatment response are unclear. We hypothesized that baseline delayed verbal recall, a sensitive measure for post-TBI chronic cognitive decline, would predict therapeutic effects of HD-tDCS targeting the pre-SMA/dACC for verbal retrieval deficits. Standardized verbal retrieval measures were administered at baseline, immediately after and 8 weeks after treatment completion. We applied mixed generalized linear modeling as a post-hoc subgroup analysis to the verbal retrieval scores that showed significant improvement in Motes at el. (2020) to examine effects of active stimulation across the groups with baseline-intact delayed recall (N = 10) and baseline-impaired delayed recall (N = 8), compared to sham (N = 7). Individuals with impaired baseline delayed recall showed significant improvement (compared to baseline) in both category fluency and color-word inhibition/switch, while individuals with intact delayed recall showed significant improvement only in color-word inhibition/switch. Baseline delayed verbal recall may therefore be considered as a predictor for future electromodulation studies targeting frontal structures to treat TBI-related verbal deficits.

针对前补充运动区/背侧前扣带皮层 (pre-SMA/dACC) 的阳极高清经颅直流电刺激 (HD-tDCS) 最近被证明可以改善患有慢性创伤性脑损伤 (TBI) 的退伍军人的言语检索缺陷（Motes 等人，2020），但治疗反应的预测因素尚不清楚。我们假设基线言语回忆延迟（TBI 后慢性认知能力下降的敏感指标）可以预测 HD-tDCS 针对 SMA/dACC 前的言语检索缺陷的治疗效果。在基线、治疗结束后立即和治疗完成后 8 周进行标准化言语检索测量。我们将混合广义线性模型应用为言语检索分数的事后亚组分析，该分数显示 Motes 在 el 中的显着改善。 (2020) 检查基线完整延迟回忆 (N = 10) 和基线受损延迟回忆 (N = 8) 组与假刺激组 (N = 7) 相比主动刺激的效果。基线延迟回忆受损的个体在类别流畅性和颜色词抑制/转换方面均表现出显着改善（与基线相比），而延迟回忆完整的个体仅在颜色词抑制/切换方面表现出显着改善。因此，基线延迟言语回忆可能被视为未来针对额叶结构的电调节研究的预测因子，以治疗 TBI 相关的言语缺陷。