Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for precisely delivering drug molecules into target tissues either through the systemic circulation or via localized injections for treating chronic diseases like diabetes, cancer, and brain disorders as well as for age-related eye diseases. LADDS have been shown to prolong drug release from 24 h up to 3 years depending on characteristics of the drug and delivery system. LADDS can offer potentially safer, more effective, and patient friendly treatment options compared to more invasive modes of drug administration such as repeated injections or minor surgical intervention. Whilst there is no single technology or definition that can comprehensively embrace LADDS; for the purposes of this review, these systems include solid implants, inserts, transdermal patches, wafers and in situ forming delivery systems. This review covers common chronic illnesses, where candidate drugs have been incorporated into LADDS, examples of marketed long-acting pharmaceuticals, as well as newly emerging technologies, used in the fabrication of LADDS.

非口服长效药物输送系统 (LADDS) 包含一系列技术，可通过全身循环或通过局部注射将药物分子精确输送到目标组织，以治疗糖尿病、癌症和脑部疾病等慢性疾病以及与年龄有关的眼部疾病。LADDS 已被证明可将药物释放时间从 24 小时延长至 3 年，具体取决于药物和递送系统的特性。与重复注射或小手术干预等更具侵入性的给药方式相比，LADDS 可以提供潜在的更安全、更有效和对患者友好的治疗选择。虽然没有单一的技术或定义可以全面包含 LADDS；就本综述而言，这些系统包括固体植入物、插入物、透皮贴剂、晶圆和原位形成输送系统。这篇综述涵盖了常见的慢性疾病，其中候选药物已被纳入 LADDS，已上市的长效药物的例子，以及用于制造 LADDS 的新兴技术。