Abstract

Context

Various herbal medicines are thought to be useful in the management of cardiometabolic disease and its risk factors. Ganoderma lucidum (Curtis) P. Karst. (Ganodermataceae), also known as Lingzhi, has received considerable attention for various indications, including some related to the prevention and treatment of cardiovascular and metabolic disease by ameliorating major cardiovascular risk factors.

Objective

This review focuses on the major studies of the whole plant, plant extract, and specific active compounds isolated from G. lucidum in relation to the main risk factors for cardiometabolic disease.

Methods

References from major databases including PubMed, Web of Science, and Google Scholar were compiled. The search terms used were Ganoderma lucidum, Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, antihypertensive, and anti-inflammatory.

Results

A number of in vitro studies and in vivo animal models have found that G. lucidum possesses antioxidative, antihypertensive, hypoglycaemic, lipid-lowering, and anti-inflammatory properties, but the health benefits in clinical trials are inconsistent. Among these potential health benefits, the most compelling evidence thus far is its hypoglycaemic effects in patients with type 2 diabetes or hyperglycaemia.

Conclusions

The inconsistent evidence about the potential health benefits of G. lucidum is possibly because of the use of different Ganoderma formulations and different study populations. Further large controlled clinical studies are therefore needed to clarify the potential benefits of G. lucidum preparations standardised by known active components in the prevention and treatment of cardiometabolic disease.

中文翻译：

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灵芝对心血管和代谢疾病风险的有益作用

 抽象的

 语境

各种草药被认为可用于治疗心脏代谢疾病及其危险因素。灵芝（Curtis）P.喀斯特。灵芝（灵芝科），又名灵芝，因其多种适应症而受到广泛关注，其中包括一些通过改善主要心血管危险因素来预防和治疗心血管和代谢疾病的适应症。

 客观的

本综述重点关注从灵芝中分离的全草、植物提取物和特定活性化合物与心脏代谢疾病主要危险因素相关的主要研究。

 方法

编译了来自 PubMed、Web of Science 和 Google Scholar 等主要数据库的参考文献。使用的检索词为灵芝、灵芝、灵芝、心血管、降血糖、糖尿病、血脂异常、抗高血压和抗炎。

 结果

多项体外研究和体内动物模型发现灵芝具有抗氧化、降压、降血糖、降脂、抗炎等功效，但临床试验中的健康益处并不一致。在这些潜在的健康益处中，迄今为止最令人信服的证据是它对 2 型糖尿病或高血糖患者的降血糖作用。

 结论

关于灵芝潜在健康益处的证据不一致可能是因为使用了不同的灵芝配方和不同的研究人群。因此，需要进一步的大型对照临床研究来阐明已知活性成分标准化的灵芝制剂在预防和治疗心脏代谢疾病方面的潜在益处。