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Single-cell profiling reveals distinct immune phenotypes that contribute to ischaemia-reperfusion injury after steatotic liver transplantation
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-09-01 , DOI: 10.1111/cpr.13116
Xinyu Yang 1, 2, 3, 4, 5 , Di Lu 1, 2, 3, 4, 5 , Rui Wang 1, 2, 3, 4, 5 , Zhengxing Lian 1, 2, 3, 4, 5 , Zuyuan Lin 1, 2, 3, 4, 5 , Jianyong Zhuo 1, 2, 3, 4, 5 , Hao Chen 1, 2, 3, 4, 5 , Modan Yang 1, 2, 3, 4, 5 , Winyen Tan 1, 2, 3, 4, 5 , Mengfan Yang 1, 2, 3, 4, 5 , Xuyong Wei 1, 2, 3, 4, 5 , Qiang Wei 1, 2, 3, 4, 5 , Shusen Zheng 2, 3, 4, 5, 6 , Xiao Xu 1, 2, 3, 4, 5
Affiliation  

The discrepancy between supply and demand of organ has led to an increased utilization of steatotic liver for liver transplantation (LT). Hepatic steatosis, however, is a major risk factor for graft failure due to increased susceptibility to ischaemia-reperfusion (I/R) injury during transplantation.

中文翻译:

单细胞分析揭示了导致脂肪肝移植后缺血再灌注损伤的独特免疫表型

器官供需之间的差异导致脂肪肝用于肝移植(LT)的使用增加。然而,由于移植过程中缺血再灌注(I/R)损伤的易感性增加,肝脂肪变性是移植失败的主要危险因素。
更新日期:2021-10-04
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