Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting,Cell Proliferation

当前位置： X-MOL 学术 › Cell Prolif. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-08-31 , DOI: 10.1111/cpr.13115
Maosen Xu ₁ , Yang Wang ₁ , Ruolan Xia ₁ , Yuquan Wei ₁ , Xiawei Wei ₁

Affiliation

The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2-CCR2 signalling axis function in malignancies. Therapeutic strategies targeting the CCL2- CCR2 axis have also shown promising effects, enriching our approaches for fighting against cancer. In this review, we summarize the role of the CCL2-CCR2 signalling axis in tumorigenesis and highlight recent studies on CCL2-CCR2 targeted therapy, focusing on preclinical studies and clinical trials.

中文翻译：

CCL2-CCR2 信号轴在癌症中的作用：机制和治疗靶向

趋化因子配体 CCL2 及其受体 CCR2 与各种癌症的发生和进展有关。CCL2可以通过多种机制激活肿瘤细胞的生长和增殖。通过与 CCR2 相互作用，CCL2 促进癌细胞迁移并将免疫抑制细胞募集到肿瘤微环境，有利于癌症的发展。在过去的几十年中，已经进行了一系列研究来探索恶性肿瘤中的 CCL2-CCR2 信号轴功能。针对 CCL2-CCR2 轴的治疗策略也显示出有希望的效果，丰富了我们对抗癌症的方法。在这篇综述中，我们总结了 CCL2-CCR2 信号轴在肿瘤发生中的作用，并重点介绍了 CCL2-CCR2 靶向治疗的最新研究，重点是临床前研究和临床试验。

更新日期：2021-10-04

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11