Co-delivery of simvastatin and demineralized bone matrix hierarchically from nanosheet-based supramolecular hydrogels for osteogenesis,Journal of Materials Chemistry B

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Co-delivery of simvastatin and demineralized bone matrix hierarchically from nanosheet-based supramolecular hydrogels for osteogenesis
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-20 , DOI: 10.1039/d1tb01256h
Xiao Zhang _{1,

2} , Jiabing Fan ₂ , Chen Chen ₂ , Tara Aghaloo ₃ , Min Lee _{2,

4}

Affiliation

Supramolecular hydrogels are widely used as 3D scaffolds and delivery platforms in tissue engineering applications. However, hydrophobic therapeutic agents exhibit weak compatibility in hydrogel scaffolds along with aggregation and precipitation. Herein, simvastatin drugs used as BMP-2 stimulators are encapsulated into the layer space of LAPONITE® via electrostatic interactions and ion exchange efficiently, and supramolecular hydrogels could be fabricated with a self-healing, injectable and sustained drug release nature. Hydrogels encapsulated with 10 μg mL⁻¹ simvastatin drug show good osteogenic differentiation in vitro. Moreover, the loading of demineralized bone matrix particles could enhance the capacity for osteogenesis via improving the expression of BMP-2 synergistically. The integrated hydrogels could be implanted into cranial defect sites for bone regeneration in vivo. This work provides the first demonstration of molecular and supramolecular engineering of hydrogels to load osteoinductive agents hierarchically for bone regeneration, contributing to the development of a brand-new strategy for dealing with compatibility between scaffolds and osteogenic agents.

中文翻译：

基于纳米片的超分子水凝胶分层共递送辛伐他汀和脱矿骨基质用于成骨

超分子水凝胶被广泛用作组织工程应用中的 3D 支架和递送平台。然而，疏水性治疗剂在水凝胶支架中表现出弱的相容性以及聚集和沉淀。在此，用作 BMP-2 刺激剂的辛伐他汀药物通过静电相互作用和离子交换有效地封装到 LAPONITE® 的层空间中，并且可以制造具有自愈、可注射和持续药物释放性质的超分子水凝胶。用 10 μg mL ^-1辛伐他汀药物包封的水凝胶在体外显示出良好的成骨分化。此外，脱矿骨基质颗粒的负载可以通过以下方式增强成骨能力协同改善 BMP-2 的表达。集成的水凝胶可以植入颅骨缺损部位，用于体内骨再生。这项工作首次展示了水凝胶的分子和超分子工程以分层加载骨诱导剂以进行骨再生，有助于开发一种全新的策略来处理支架和成骨剂之间的相容性。

更新日期：2021-09-01

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