Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances,Journal of Materials Chemistry B

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Structural diversity of nanoscale zirconium porphyrin MOFs and their photoactivities and biological performances
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-16 , DOI: 10.1039/d1tb01311d
Junli Zhou _{1,

2} , Yite Li _{1,

2} , Lei Wang ₁ , Zhigang Xie _{1,

2}

Affiliation

Photoactive MOF-based delivery systems are highly attractive for photodynamic therapy (PDT), but the fundamental interplay among structural parameters and photoactivity and biological properties of these MOFs remains unclear. Herein, porphyrinic MOF isomers (TCPP-MOFs), constructing using the same building blocks into distinct topologies, have been selected as ideal models to understand this problem. Both the intramolecular distances and molecular polarization within TCPP-MOFs isomers collectively contribute to the photoactivity of generating reactive oxygen species. Remarkably, the morphology-determined endocytic pathways and cytotoxicity, as well as good biocompatibility have been confirmed for TCPP-MOF isomers without any chemical modification for the first time. Besides the topology-dependent photoactive regulation, this work also provides in-depth insights into the biological effect from the MOF nanoparticles with controllable structural factors, benefiting further in vivo applications and clinical transformation.

中文翻译：

纳米级锆卟啉MOFs的结构多样性及其光活性和生物学性能

基于光活性 MOF 的递送系统对光动力疗法 (PDT) 非常有吸引力，但这些 MOF 的结构参数与光活性和生物学特性之间的基本相互作用仍不清楚。在此，卟啉 MOF 异构体 (TCPP-MOF) 使用相同的构建块构建成不同的拓扑结构，已被选为理解该问题的理想模型。TCPP-MOFs 异构体中的分子内距离和分子极化共同有助于产生活性氧的光活性。值得注意的是，首次证实了未经任何化学修饰的 TCPP-MOF 异构体具有由形态决定的内吞途径和细胞毒性以及良好的生物相容性。除了拓扑相关的光活性调节外，体内应用和临床转化。

更新日期：2021-09-01

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