Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence,Molecular Genetics & Genomic Medicine

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Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence
Molecular Genetics & Genomic Medicine ( IF 1.5 ) Pub Date : 2021-09-01 , DOI: 10.1002/mgg3.1789
Huan Liu _{1,

2} , Wei Zhang ₂ , Xiao-Dong Deng ₂ , Ying Ma ₃ , Yun Liu _{2,

4}

Affiliation

The quinone oxidoreductase 1 (NQO1) gene was involved in the pathophysiological process of illicit drugs abuse, and its polymorphisms might be associated with methamphetamine (METH) dependence susceptibility. The purpose of this study was to examine the NQO1 mRNA and protein levels and to analyze the 609C/T polymorphism (rs1800566) between METH-dependent patients and controls.

中文翻译：

NQO1水平及其遗传多态性与甲基苯丙胺依赖易感性的关系

醌氧化还原酶1（NQO1）基因参与非法药物滥用的病理生理过程，其多态性可能与甲基苯丙胺（METH）依赖易感性相关。本研究的目的是检查NQO1 mRNA 和蛋白质水平，并分析 METH 依赖患者和对照之间的 609C/T 多态性 (rs1800566)。

更新日期：2021-11-10

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