The two main components from a Nelumbo nucifera leaf extract (NnEx) were investigated for their ability to prevent triglyceride accumulation and promoting lipolysis. Sun-dried Nelumbo nucifera leaves were immersed in hot water to extract the soluble components, and the resulting solution was analyzed by LC-MS and nuclear magnetic resonance. The results showed that quercetin-3-O-ß-glucuronide (Q3GA) and quercetin were the key components of the NnEx. In vitro experiments confirmed that quercetin and Q3GA functioned in lipid metabolism by promoting triglyceride degradation through inhibition of the cAMP pathway. In vivo experiments showed that NnEx ingestion inhibited the accumulation of neutral fats in ICR mice and transitioned the hepatocytes of type II diabetic KK-Ay mice out of glycogenosis. These results highlight the ability of NnEx to control metabolism by modulating fat and sugar absorption and may provide an interesting novel treatment for obesity and related lifestyle diseases such as type II diabetes.

研究了Nelumbo nucifera叶提取物 (NnEx)的两种主要成分防止甘油三酯积累和促进脂肪分解的能力。将晒干的荷花叶浸入热水中提取可溶性成分，所得溶液通过LC-MS和核磁共振进行分析。结果表明，槲皮素-3 - O - β-葡糖苷酸 (Q3GA) 和槲皮素是 NnEx 的关键成分。体外实验证实，槲皮素和 Q3GA 通过抑制 cAMP 途径促进甘油三酯降解，从而在脂质代谢中发挥作用。体内实验表明，NnEx 摄入抑制了 ICR 小鼠中性脂肪的积累，并使 II 型糖尿病 KK-Ay 小鼠的肝细胞摆脱糖原沉积。这些结果突出了 NnEx 通过调节脂肪和糖的吸收来控制新陈代谢的能力，并可能为肥胖和相关的生活方式疾病（如 II 型糖尿病）提供一种有趣的新疗法。