Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions, including ischemic tissue damage, infection, neurodegeneration, and cancer. The cellular machinery responsible for the execution of ferroptosis integrates multiple pro-survival or pro-death signals from subcellular organelles and then ‘decides’ whether to engage the lethal process or not. Here, we outline the evidence implicating different organelles (including mitochondria, lysosomes, endoplasmic reticulum, lipid droplets, peroxisomes, Golgi apparatus, and nucleus) in the ignition or avoidance of ferroptosis, while emphasizing their potential relevance for human disease and their targetability for pharmacological interventions.

铁死亡是一种以铁依赖性脂质过氧化为特征的细胞死亡方式，与多种病理状况的发展有关，包括缺血性组织损伤、感染、神经变性和癌症。负责执行铁死亡的细胞机制整合来自亚细胞细胞器的多个促生存或促死亡信号，然后“决定”是否参与致死过程。在这里，我们概述了不同细胞器（包括线粒体、溶酶体、内质网、脂滴、过氧化物酶体、高尔基体和细胞核）在引发或避免铁死亡中的证据，同时强调它们与人类疾病的潜在相关性及其药理学靶向性干预措施。