Non-enzymatic glucose sensors outperform enzymatic ones in terms of cost, sensitivity, stability, and operating duration. Though highly sensitive, it is still desirable to further improve the sensitivity of non-enzymatic glucose sensors to detect a trace amount of glucose in sweat and other biofluids. Among the demonstrated effective approaches using bimetals or 3D porous structures, the porous laser-induced graphene (LIG) on flexible polymers showcases good conductivity and a simple fabrication process for the integration of sensing materials. The uniform electroless plating of the nickel and gold layer on LIG electrodes demonstrates significantly enhanced sensitivity and a large linear range for glucose sensing. The sensor with the porous LIG foam exhibits a high sensitivity of 1080 μA mM⁻¹ cm⁻², whereas a further increased sensitivity of 3500 μA mM⁻¹ cm⁻² is obtained with LIG fibers (LIGF). Impressively, a large linear range (0 – 30 mM) can be achieved by changing the bias voltage from 0.5 to 0.1 V due to the Au coating. Because the existing non-enzymatic glucose sensors are limited to use in basic solutions, their application in wearable electronics is elusive. In addition to the reduced requirement for the base solution, this work integrates a porous encapsulating reaction cavity containing alkali solutions with a soft, skin-interfaced microfluidic component to provide integrated microfluidic non-enzymatic glucose sensors for sweat sampling and glucose sensing. The accurate glucose measurements from the human sweat and cell culture media showcase the practical utility, which opens up opportunities for the non-enzymatic glucose sensors in wearable electronics.

非酶葡萄糖传感器在成本、灵敏度、稳定性和工作持续时间方面优于酶葡萄糖传感器。尽管高度灵敏，但仍需要进一步提高非酶葡萄糖传感器的灵敏度以检测汗液和其他生物液中的痕量葡萄糖。在使用双金属或 3D 多孔结构的有效方法中，柔性聚合物上的多孔激光诱导石墨烯 (LIG) 表现出良好的导电性和用于集成传感材料的简单制造工艺。 LIG 电极上镍和金层的均匀化学镀表明葡萄糖传感的灵敏度显着增强，线性范围大。具有多孔LIG泡沫的传感器表现出1080 μA mM ^-1 cm ^-2的高灵敏度，而使用LIG纤维（LIGF）获得了3500 μA mM ^-1 cm ^-2的进一步提高的灵敏度。令人印象深刻的是，由于有 Au 涂层，通过将偏置电压从 0.5 V 更改为 0.1 V 可以实现较大的线性范围 (0 – 30 mM)。由于现有的非酶葡萄糖传感器仅限于在基本解决方案中使用，因此它们在可穿戴电子产品中的应用是难以捉摸的。除了减少对基础溶液的需求外，这项工作还将含有碱溶液的多孔封装反应腔与柔软的皮肤界面微流体组件集成在一起，为汗液采样和葡萄糖传感提供集成微流体非酶葡萄糖传感器。来自人体汗液和细胞培养基的准确葡萄糖测量展示了实用性，这为可穿戴电子产品中的非酶葡萄糖传感器开辟了机会。