Journal of Advanced Research ( IF 11.4 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.jare.2021.08.012 Lian Wang 1, 2 , Xin Xie 3 , Bowen Ke 4 , Wei Huang 3 , Xian Jiang 1, 2 , Gu He 1, 2
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Background
Endogenous gasotransmitters are small gaseous mediators that can be generated endogenously by mammalian organisms. The dysregulation of the gasotransmitter system is associated with numerous disorders ranging from inflammatory diseases to cancers. However, the relevance of these endogenous gasotransmitters, prodrug donors and inhibitors in inflammatory dermatological disorders has not yet been thoroughly reviewed and discussed.
Aim of review
This review discusses the recent progress and will provide perspectives on endogenous gasotransmitters in the context of inflammatory dermatological disorders.
Key scientific concepts of review
Endogenous gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) are signaling molecules that regulate several physiological and pathological processes. In addition, sulfur dioxide (SO₂), methane (CH4), hydrogen gas (H2), ammonia (NH3), and carbon dioxide (CO2) can also be generated endogenously and may take part in physiological and pathological processes. These signaling molecules regulate inflammation, vasodilation, and oxidative stress, offering therapeutic potential and attracting interest in the field of inflammatory dermatological disorders including psoriasis, atopic dermatitis, acne, rosacea, and chronic skin ulcers. The development of effective gas donors and inhibitors is a promising alternative to treat inflammatory dermatological disorders with controllable and precise delivery in the future.
中文翻译：
炎症性皮肤病中内源性气体递质的最新进展
背景
内源性气体递质是可以由哺乳动物生物内源性产生的小型气体介质。气体递质系统的失调与从炎症性疾病到癌症的许多疾病有关。然而，这些内源性气体递质、前药供体和抑制剂在炎症性皮肤病中的相关性尚未得到彻底审查和讨论。
审查目的
本综述讨论了最近的进展，并将提供关于炎症性皮肤病背景下内源性气体递质的观点。
审查的关键科学概念
内源性气体递质一氧化氮 (NO)、一氧化碳 (CO) 和硫化氢 (H 2 S) 是调节多种生理和病理过程的信号分子。此外，二氧化硫 (SO₂)、甲烷 (CH 4 )、氢气 (H 2 )、氨气 (NH 3 ) 和 二氧化碳 (CO 2) 也可以内源性产生，并可能参与生理和病理过程。这些信号分子调节炎症、血管舒张和氧化应激，提供治疗潜力，并在包括银屑病、特应性皮炎、痤疮、红斑痤疮和慢性皮肤溃疡在内的炎症性皮肤病领域引起人们的兴趣。开发有效的气体供体和抑制剂是未来治疗炎症性皮肤病的一种有前途的替代方案，可控制和精确输送。
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