Abstract

Both tantalum (Ta) and silicon nitride (SN) exhibit osteogenic bioactivity and antibacterial property. In addition, as a biomaterial for bone repair, polyetheretherketone (PEEK) has outstanding biocompatibility and mechanical performances while it is biologically inert. In this study, by blending PEEK with Ta and SN nanoparticles, respectively, Ta/PEEK composite (TPC) and SN/PEEK composite (SPC) were fabricated for load-bearing bone repair. The surface roughness, hydrophilicity and surface energy of TPC containing Ta nanoparticles were higher than SPC containing SN nanoparticles and PEEK. In addition, TPC with Ta nanoparticles exhibited low antibacterial property while SPC with SN nanoparticles showed high bacterial property. Moreover, the MC3T3-E1 cells responses (e.g. proliferation and differentiation) to TPC was the highest while PEEK was the lowest in vitro. Furthermore, new bone formation and osseointegration for TPC was the highest while PEEK was the lowest in vivo. In conclusion, compared with PEEK, addition of Ta and SN nanoparticles into PEEK fabricated bioactive composites of TPC and SPC with optimized surface property, which played crucial roles in inducing cellular response/bone regeneration. Although the osteogenic activity of SPC was lower than TPC, SPC exhibited osteogenic activity and good antibacterial property, which could prevent infection from bacterial. Therefore, SPC would have better potential for bone substitute.

 抽象的

钽（Ta）和氮化硅（SN）都具有成骨生物活性和抗菌特性。此外，作为骨修复生物材料，聚醚醚酮（PEEK）在具有生物惰性的同时，还具有出色的生物相容性和机械性能。在本研究中，通过将 PEEK 分别与 Ta 和 SN 纳米颗粒共混，制备了 Ta/PEEK 复合材料（TPC）和 SN/PEEK 复合材料（SPC），用于承重骨修复。含Ta纳米颗粒的TPC的表面粗糙度、亲水性和表面能均高于含SN纳米颗粒的SPC和PEEK。此外，含有Ta纳米颗粒的TPC表现出较低的抗菌性能，而含有SN纳米颗粒的SPC则表现出较高的抗菌性能。此外，体外MC3T3-E1细胞对TPC的反应（如增殖和分化）最高，而PEEK最低。此外，在体内， TPC的新骨形成和骨整合最高，而PEEK最低。总之，与 PEEK 相比，在 PEEK 中添加 Ta 和 SN 纳米颗粒可制备具有优化表面性能的 TPC 和 SPC 生物活性复合材料，在诱导细胞反应/骨再生中发挥关键作用。虽然SPC的成骨活性低于TPC，但SPC具有成骨活性和良好的抗菌性能，可以防止细菌感染。因此，SPC作为骨替代材料具有更好的潜力。