Immune checkpoint inhibitor therapies induce potent anti-tumour immunity as well as immune-related adverse events that manifest as autoimmune disease — particularly thyroiditis. Translational studies and preclinical models are beginning to unravel the molecular processes that mediate these adverse events; this knowledge might enable the development of ICIs with anti-tumour efficacy and improved safety margins.

中文翻译：

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深入了解免疫检查点抑制剂诱发的甲状腺炎

免疫检查点抑制剂疗法可诱导有效的抗肿瘤免疫以及表现为自身免疫性疾病——尤其是甲状腺炎的免疫相关不良事件。转化研究和临床前模型开始解开介导这些不良事件的分子过程；这些知识可能有助于开发具有抗肿瘤功效和提高安全性的 ICI。