This review intends to provide an overview on the role of halide anions in the development of the research area of asymmetric anion-binding organocatalysis. Key early elucidation studies with chloride as counter-anion confirmed this type of alternative activation, which was then exploited in several processes and contributed to the advance and consolidation of anion-binding catalysis as a field. Thus, the use of the halide in the catalyst–anion complex as both a mere counter-anion spectator or an active nucleophile has been depicted, along with the new trends toward additional noncovalent contacts within the HB-donor catalyst and supramolecular interactions to both the anion and the cationic reactive species.

中文翻译：

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卤化物在不对称阴离子结合有机催化中作为多功能阴离子

本综述旨在概述卤化物阴离子在不对称阴离子结合有机催化研究领域的发展中的作用。用氯作为反阴离子的早期关键阐明研究证实了这种类型的替代活化，然后在几个过程中加以利用，并促进了阴离子结合催化作为一个领域的进步和巩固。因此，已经描述了在催化剂 - 阴离子复合物中使用卤化物作为单纯的反阴离子旁观者或活性亲核试剂，以及在 HB 供体催化剂内增加非共价接触和超分子相互作用的新趋势阴离子和阳离子活性物质。