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Photodynamic and Photothermal Ce6-Modified Gold Nanorod as a Potent Alternative Candidate for Improved Photoinactivation of Bacteria
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-09-01 , DOI: 10.1021/acsabm.1c00474 Baoqu Zhang 1 , Hongjun Yan 2 , Zhouting Meng 2 , Peiyuan Li 2 , Xiantao Jiang 1 , Zihua Wu 1 , Jun-An Xiao 1 , Wei Su 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-09-01 , DOI: 10.1021/acsabm.1c00474 Baoqu Zhang 1 , Hongjun Yan 2 , Zhouting Meng 2 , Peiyuan Li 2 , Xiantao Jiang 1 , Zihua Wu 1 , Jun-An Xiao 1 , Wei Su 1
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The global rise of antibiotic resistance of pathogenic bacteria has become an increasing medical and public concern, which is further urging the development of antimicrobial channels for treating infectious diseases. The combination of photodynamic therapy (PDT) with photothermal therapy (PTT) has been considered as a promising alternative way for the replacement of traditional antibiotic therapy. In this research, the newly fabricated Chlorin-e6 (Ce6) conjugated mesoporous silica-coated AuNRs, designated AuNR@SiO2-NH2-Ce6, exhibited synergistic photothermal effects and single oxygen localized generation property, and showed stronger photoinactivation for bacteria compared with Ce6. AuNR@SiO2-NH2-Ce6 can anchor to the cell membrane and accumulate in the interior of cells. Furthermore, the unique porous structure of AuNR@SiO2NH2 enabled Ce6 encapsulation in the mesopores and was subsequently released and activated by photothermic effect, allowing the generated single oxygen to penetrate into the cytoplasmic membrane or directly enter the interior of bacteria cells, thus overcoming the inherent defects of single oxygen. AuNR@SiO2-NH2-Ce6 not only damaged the integrity of the cell membrane of bacteria but also facilitated the cellular permeation and accumulation of external nanoagents in the bacteria upon light irradiation. In addition, AuNR@SiO2-NH2-Ce6 exhibited negligible cytotoxicity toward mammalian cells and hemolytic activity. Therefore, AuNR@SiO2-NH2-Ce6 may be highly promising candidates as topical antibacterial agents, and this study has wide implications on the design of next-generation antimicrobial agents.
中文翻译：
光动力和光热 Ce6 改性金纳米棒作为改进细菌光灭活的有效替代候选物
全球病原菌对抗生素耐药性的上升已成为医学和公众日益关注的问题，这进一步推动了治疗传染病的抗菌渠道的发展。光动力疗法（PDT）与光热疗法（PTT）的结合被认为是替代传统抗生素疗法的一种有希望的替代方法。在本研究中，新制备的 Chlorin-e6 (Ce6) 共轭介孔二氧化硅包覆的 AuNRs，命名为 AuNR@SiO 2 -NH 2 -Ce6，表现出协同的光热效应和单一的氧定域产生特性，与细菌相比，表现出更强的光灭活能力。铈6。AuNR@SiO 2 -NH 2-Ce6可以锚定在细胞膜上并在细胞内部积累。此外，AuNR@SiO 2 NH 2独特的多孔结构使Ce6能够包裹在介孔中，随后通过光热效应释放和活化，使产生的单氧渗透到细胞质膜或直接进入细菌细胞内部，从而克服了单氧的固有缺陷。AuNR@SiO 2 -NH 2 -Ce6不仅破坏了细菌细胞膜的完整性，而且在光照射下促进了外部纳米剂在细菌中的细胞渗透和积累。此外，AuNR@SiO 2 -NH 2-Ce6 对哺乳动物细胞的细胞毒性和溶血活性可忽略不计。因此，AuNR@SiO 2 -NH 2 -Ce6 可能是非常有前景的外用抗菌剂候选者，该研究对下一代抗菌剂的设计具有广泛的意义。
更新日期：2021-09-20
中文翻译：
光动力和光热 Ce6 改性金纳米棒作为改进细菌光灭活的有效替代候选物
全球病原菌对抗生素耐药性的上升已成为医学和公众日益关注的问题，这进一步推动了治疗传染病的抗菌渠道的发展。光动力疗法（PDT）与光热疗法（PTT）的结合被认为是替代传统抗生素疗法的一种有希望的替代方法。在本研究中，新制备的 Chlorin-e6 (Ce6) 共轭介孔二氧化硅包覆的 AuNRs，命名为 AuNR@SiO 2 -NH 2 -Ce6，表现出协同的光热效应和单一的氧定域产生特性，与细菌相比，表现出更强的光灭活能力。铈6。AuNR@SiO 2 -NH 2-Ce6可以锚定在细胞膜上并在细胞内部积累。此外，AuNR@SiO 2 NH 2独特的多孔结构使Ce6能够包裹在介孔中，随后通过光热效应释放和活化，使产生的单氧渗透到细胞质膜或直接进入细菌细胞内部，从而克服了单氧的固有缺陷。AuNR@SiO 2 -NH 2 -Ce6不仅破坏了细菌细胞膜的完整性，而且在光照射下促进了外部纳米剂在细菌中的细胞渗透和积累。此外，AuNR@SiO 2 -NH 2-Ce6 对哺乳动物细胞的细胞毒性和溶血活性可忽略不计。因此，AuNR@SiO 2 -NH 2 -Ce6 可能是非常有前景的外用抗菌剂候选者，该研究对下一代抗菌剂的设计具有广泛的意义。
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