Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) has been proved to play a vital role in human cancers. Nevertheless, the exact role of ENTPD1 in thyroid carcinoma (THCA) remained unclear. This study aimed to evaluate its prognostic value and reveal the potential regulatory mechanism in THCA. (1) Higher expression of ENTPD1 was found in THCA tissue compared with normal tissue (all P < 0.05). ENTPD1 expression was associated with age, sub-type and clinical stage of THCA patients (all P < 0.05). Immunohistochemistry showed its higher expression in patients with early stage. (2) ENTPD1 high expression was associated with favorable overall survival of THCA patients (all P < 0.05), especially for male patients and those with advanced stage, B-cells and Natural killer T-cells decreased (all P < 0.05). (3) Pathway analysis indicated that ENTPD1 mainly participated in metabolic process and negatively regulated metabolism-related pathway such as butanoate metabolism, pyruvate metabolism and fatty acid metabolism ((all P < 0.05). (4) ENTPD1 appeared genetic alteration in THCA, and the main mutation type of ENTPD1 was missense substitution (15.89%). (5) A weak correlation between ENTPD1 expression and methylation was found (P < 0.001). Methylation of ENTPD1 in THCA was lower than in normal group (P < 0.001), but it did not correlate with any clinical phenotypes of THCA patients. ENTPD1 was highly expressed in THCA, and ENTPD1 high expression contributed to the prognosis of THCA patients. The present study inferred that ENTPD1 might serve as a metabolism-related gene and play a critical role in THCA through regulating metabolic pathways.

中文翻译：

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外核苷三磷酸二磷酸水解酶1高表达在甲状腺癌中的有利作用

外核苷三磷酸二磷酸水解酶 1 (ENTPD1) 已被证明在人类癌症中起着至关重要的作用。然而，ENTPD1 在甲状腺癌 (THCA) 中的确切作用仍不清楚。本研究旨在评估其预后价值并揭示 THCA 的潜在调控机制。(1) ENTPD1在THCA组织中的表达高于正常组织(均P < 0.05)。ENTPD1 表达与 THCA 患者的年龄、亚型和临床分期相关（均 P < 0.05）。免疫组化显示其在早期患者中表达较高。(2) ENTPD1高表达与THCA患者良好的总生存相关（均P < 0.05），尤其是男性患者和晚期患者，B细胞和自然杀伤T细胞减少（均P < 0.05）。