Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a pathogen of global concern. In this study, both phenotypic and genotypic tests were used to detect hvKp. Antimicrobial resistance profiles and clonal relatedness of clinical isolates were also determined. We found that 34.2% (163/477) of the isolates were tellurite resistant, and among them 102 hvKp isolates detected with iucA or iutA or peg-344 as molecular markers. The blaSHV (80.4%), followed by blaCTX-M-15 (76.5%) and blaTEM (67.6%), blaOXA-48 (53.9%), and blaNDM-1 (32.3%) were detected, while blaKPC-1 was not present in any hvKp isolates. It was found that the majority of hvKp isolates belonged to capsular serotype K20 and ompK36 group C, which is related to clonal group (CG) 23 (e.g. ST23). A high percentage of multidrug-resistant hvKp (76.6%) and high resistance to imipenem (67%) indicated a serious problem that should be addressed in the clinical setting.

中文翻译：

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从伊朗两家教学医院的临床样本中分离出的高毒力肺炎克雷伯菌的面孔


高毒力肺炎克雷伯菌 (hvKp) 已成为全球关注的病原体。在本研究中，使用表型和基因型测试来检测 hvKp。还确定了临床分离株的抗菌素耐药性和克隆相关性。我们发现 34.2% (163/477) 的分离株具有亚碲酸盐抗性，其中 102 个 hvKp 分离株以 iucA 或 iutA 或 peg-344 作为分子标记检测。检测到 blaSHV (80.4%)，其次是 blaCTX-M-15 (76.5%) 和 blaTEM (67.6%)、blaOXA-48 (53.9%) 和 blaNDM-1 (32.3%)，而 blaKPC-1 未检测到存在于任何 hvKp 分离株中。结果发现，大多数hvKp分离株属于荚膜血清型K20和ompK36 C组，与克隆组（CG）23（例如ST23）相关。多重耐药 hvKp 的高比例（76.6%）和对亚胺培南的高耐药性（67%）表明这是一个应该在临床环境中解决的严重问题。