Caspase-9 (CASP9) and caspase-10 (CASP10) polymorphisms were associated with human cancers; however, the results remain controversial. In this meta-analysis, we aimed to estimate the relationship among CASP9 (rs1052576, rs1052571, rs4645978, rs4645981, rs4645982, rs2308950) and CASP10 (rs13006529, rs13010627, rs3900115) polymorphisms and the overall risk of cancers. Relevant studies were obtained from Web of Science, MEDLINE, PubMed, Scopus, and Google scholar databases (updated January 1, 2021). Odds ratio (OR) and 95% confidence intervals (CIs) were measured to estimate the strength of association. Our meta-analysis included 40 studies. The rs4645981 significantly enhanced the risk of cancer under TT vs. CC (OR = 2.42), TC vs. CC (OR = 1.55), TT+ TC vs. CC (OR = 1.66), TT vs. TC + CC (OR = 1.91), and T vs. C (OR = 1.57) inheritance models. As for the rs1052571 variant, increased risk of cancer was observed under TT vs. CC (OR =1.22), TC vs. CC (OR = 1.17), and TT+ TC vs. CC (OR = 1.18) models. The stratified analysis showed a significant correlation between rs4645978 or rs4645981 polymorphisms and cancer risk, while in Asians rs4645978 conferred an increased risk of colorectal, lung, and prostate cancer. Both rs4645981 and rs1052576 polymorphisms were correlated with an enhanced risk of lung cancer. In conclusion, our meta-analysis suggested that CASP9 rs4645981 and rs1052571 polymorphisms are associated with overall cancer risk. More studies on larger populations are warranted to validate these associations.

Caspase-9 ( CASP9 ) 和 caspase-10 ( CASP10 ) 多态性与人类癌症相关；然而，结果仍然存在争议。在这项荟萃分析中，我们旨在估计CASP9（rs1052576、rs1052571、rs4645978、rs4645981、rs4645982、rs2308950）和CASP10 之间的关系(rs13006529, rs13010627, rs3900115) 多态性和癌症的总体风险。相关研究来自 Web of Science、MEDLINE、PubMed、Scopus 和 Google 学术数据库（2021 年 1 月 1 日更新）。测量优势比 (OR) 和 95% 置信区间 (CI) 以估计关联强度。我们的荟萃分析包括 40 项研究。rs4645981 在 TT vs. CC (OR = 2.42)、TC vs. CC (OR = 1.55)、TT+ TC vs. CC (OR = 1.66)、TT vs. TC + CC (OR = 1.91) 下显着提高癌症风险)，以及 T 与 C (OR = 1.57) 继承模型。至于 rs1052571 变体，在 TT 与 CC（OR = 1.22）、TC 与 CC（OR = 1.17）和 TT+ TC 与 CC（OR = 1.18）模型下观察到癌症风险增加。分层分析显示 rs4645978 或 rs4645981 多态性与癌症风险之间存在显着相关性，而在亚洲人中，rs4645978 会增加患结直肠癌、肺癌和前列腺癌的风险。rs4645981 和 rs1052576 多态性都与肺癌风险增加相关。总之，我们的荟萃分析表明，CASP9 rs4645981 和 rs1052571 多态性与总体癌症风险相关。有必要对更大的人群进行更多的研究来验证这些关联。