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The novel bis-1,2,4-triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-08-30 , DOI: 10.1128/aac.00311-21 Katherine M Ellis 1 , Leonardo Lucantoni 2 , Marina Chavchich 3 , Matthew Abraham 4 , Amanda De Paoli 1 , Madeline R Luth 4 , Anne-Marie Zeeman 5 , Michael J Delves 6 , Fernando Sánchez-Román Terán 6 , Ursula Straschil 6 , Jake Baum 6 , Clemens H M Kocken 5 , Stuart A Ralph 7 , Elizabeth A Winzeler 4 , Vicky M Avery 2 , Michael D Edstein 3 , Jonathan B Baell 8 , Darren J Creek 1
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-08-30 , DOI: 10.1128/aac.00311-21 Katherine M Ellis 1 , Leonardo Lucantoni 2 , Marina Chavchich 3 , Matthew Abraham 4 , Amanda De Paoli 1 , Madeline R Luth 4 , Anne-Marie Zeeman 5 , Michael J Delves 6 , Fernando Sánchez-Román Terán 6 , Ursula Straschil 6 , Jake Baum 6 , Clemens H M Kocken 5 , Stuart A Ralph 7 , Elizabeth A Winzeler 4 , Vicky M Avery 2 , Michael D Edstein 3 , Jonathan B Baell 8 , Darren J Creek 1
Affiliation
Novel bis-1,2,4-triazine compounds with potent in vitro activity against Plasmodium falciparum parasites were recently identified. The bis-1,2,4-triazines represent a unique antimalarial
pharmacophore, and are proposed to act by a novel, but as-yet-...
中文翻译：
新型 bis-1,2,4-triazine MIPS-0004373 对疟疾寄生虫的所有血液阶段表现出快速而有效的活性
最近发现了具有抗恶性疟原虫寄生虫有效体外活性的新型双-1,2,4-三嗪化合物。bis-1,2,4-triazines 代表了一种独特的抗疟药效团，并被提议通过一种新颖但尚未...
更新日期：2021-09-12
中文翻译：
新型 bis-1,2,4-triazine MIPS-0004373 对疟疾寄生虫的所有血液阶段表现出快速而有效的活性
最近发现了具有抗恶性疟原虫寄生虫有效体外活性的新型双-1,2,4-三嗪化合物。bis-1,2,4-triazines 代表了一种独特的抗疟药效团，并被提议通过一种新颖但尚未...
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