Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study),Antimicrobial Agents and Chemotherapy

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Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-08-30 , DOI: 10.1128/aac.01438-21
Vesa Cheng _{1,

2} , Mohd H Abdul-Aziz ₁ , Fay Burrows ₃ , Hergen Buscher _{4,

5} , Young-Jae Cho ₆ , Amanda Corley ₇ , Arne Diehl ₈ , Eileen Gilder ₉ , Stephan M Jakob ₁₀ , Hyung-Sook Kim ₁₁ , Bianca J Levkovich ₁₂ , Sung Yoon Lim ₆ , Shay McGuinness ₉ , Rachael Parke _{9,

13} , Vincent Pellegrino ₈ , Yok-Ai Que ₁₀ , Claire Reynolds ₄ , Sam Rudham ₄ , Steven C Wallis ₁ , Susan A Welch ₃ , David Zacharias ₁₀ , John F Fraser _{2,

14,

15,

16} , Kiran Shekar _{2,

14,

15,

16} , Jason A Roberts _{1,

17,

18} ,

Affiliation

University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queenslandgrid.1003.2University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The grid.1003.2, Brisbane, Queensland, Australia.
Adult Intensive Care Services and Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Department of Pharmacy, St Vincent's Hospital, Sydney, New South Wales, Australia.
Department of Intensive Care Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.
St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, New South Wales, Australia.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospitalgrid.412480.b, Seongnam, Republic of Korea.
Adult Intensive Care Services, The Prince Charles Hospital, Chermside, Australia.
Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, and School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospitalgrid.414055.1, Auckland, New Zealand.
Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Pharmacy, Seoul National University Bundang Hospitalgrid.412480.b, Seongnam, Republic of Korea.
Experiential Development and Graduate Education and Centre for Medicines Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
School of Nursing, The University of Auckland, Auckland, New Zealand.
Faculty of Medicine, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.
Department of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.

Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without renal replacement therapy (RRT). We also aimed to use dosing simulations to ...

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