The overarching mission of the Einstein-Nathan Shock Center (E-NSC) is to make scientific discoveries in geroscience, leveraging on the expertise in our center in 6 out of the 7 pillars of aging, and to translate their effects towards drug discovery. The relevance of this basic biology of aging discoveries to humans will be confirmed through the unique gero-human resource at E-NSC. This is achieved through services provided by E-NSC, connectivity among its members, attracting worldwide investigators, and providing them with the opportunities to become future leaders. The two central components of the E-NSC are (a) cutting-edge research programs and (b) unique E-NSC research support cores. E-NSC scientists lead NIH-supported cutting-edge research programs that integrate key hallmarks of aging including proteostasis/autophagy, metabolism/inflammaging, genetic/epigenetics, stem cells/regeneration, and translational aging/longevity. Since the inception of the E-NSC, the well-integrated, collaborative, and innovative nature of the multiple supporting state-of-the-art E-NSC research cores form the bedrock of research success at the E-NSC. The three state-of-the-art E-NSC research cores, (i) Proteostasis of Aging Core (PAC), (ii) the Health Span Core (HSC), and (iii) the Human Multi-Omics Core (HMOC), have allowed impressive expansion of translational biological research programs. Expansion was facilitated through the wealth of data coming from genomics/proteomics and metabolomic analysis on human longevity studies, due to access to a variety of biological samples from elderly subjects in clinical trials with aging-targeting drugs, and new drug design services via the PAC to target the hallmarks of aging.

爱因斯坦-内森休克中心 (E-NSC) 的首要任务是利用我们中心在衰老的 7 个支柱中的 6 个方面的专业知识，在老年科学方面取得科学发现，并将其影响转化为药物发现。这种衰老发现的基本生物学与人类的相关性将通过 E-NSC 独特的老年人力资源得到证实。这是通过 E-NSC 提供的服务、其成员之间的联系、吸引全球调查人员并为他们提供成为未来领导者的机会来实现的。E-NSC 的两个核心组成部分是 (a) 前沿研究计划和 (b) 独特的 E-NSC 研究支持核心。E-NSC 科学家领导 NIH 支持的前沿研究项目，这些项目整合了衰老的关键特征，包括蛋白质稳态/自噬，新陈代谢/炎症、遗传/表观遗传学、干细胞/再生和平移衰老/长寿。自 E-NSC 成立以来，多个支持最先进的 E-NSC 研究核心的良好集成、协作和创新性质构成了 E-NSC 研究成功的基石。三个最先进的 E-NSC 研究核心，(i) 衰老核心蛋白稳态 (PAC)，(ii) 健康跨度核心 (HSC)，和 (iii) 人类多组学核心 (HMOC) ，使转化生物学研究计划的扩展令人印象深刻。来自基因组学/蛋白质组学和人类寿命研究的代谢组学分析的大量数据促进了扩展，因为在针对衰老药物的临床试验中获得了来自老年受试者的各种生物样本，