Conductive polymers with high near-infrared absorbance, have attracted considerable attention in the design of intelligent nanomedicines for cancer therapy, especially chemo-photothermal therapy. However, the unknown long-term biosafety of conductive polymers in vivo due to non-degradability hinders their clinic application. Herein, a H₂O₂-triggered degradable conductive polymer, polyacrylic acid (PAA) stabilized poly(pyrrole-3-COOH) (PAA@PPyCOOH), is fabricated to form nanoparticles with doxorubicin (DOX) for safe and precise chemo-phototherapy. The PAA@PPyCOOH was found to be an ideal photothermal nano-agent with good dispersity, excellent biocompatibility and high photothermal conversion efficiency (56%). After further loading of doxorubicin (DOX), PAA@PPyCOOH@DOX demonstrates outstanding photothermal performance, as well as pH/H₂O₂ dual-responsive release of DOX in tumors with an acidic and overexpressed H₂O₂ microenvironment, resulting in superior chemo-photothermal therapeutic effects. The degradation mechanism of PAA@PPyCOOH is proposed to be the ring-opening reaction between the pyrrole-3-COOH unit and H₂O₂. More importantly, the nanoparticles can be specifically degraded by excess H₂O₂ in tumor, and the degradation products were confirmed to be excreted via urine and feces. In vivo therapeutic evaluation of chemo-photothermal therapy reveals tumor growth of 4T1 breast cancer model is drastically inhibited and no apparent side-effect is detected, thus indicating substantial potential in clinic application.

具有高近红外吸光度的导电聚合物在用于癌症治疗，尤其是化学光热治疗的智能纳米药物的设计中引起了相当大的关注。然而，由于不可降解性，导电聚合物在体内的长期生物安全性未知，阻碍了它们的临床应用。在此，H ₂ O ₂-触发的可降解导电聚合物，聚丙烯酸（PAA）稳定的聚（吡咯-3-COOH）（PAA@PPyCOOH），与阿霉素（DOX）一起形成纳米颗粒，用于安全和精确的化学光疗。PAA@PPyCOOH被发现是一种理想的光热纳米剂，具有良好的分散性、优异的生物相容性和高光热转换效率（56%）。在进一步加载多柔比星（DOX）后，PAA@PPyCOOH@DOX 表现出出色的光热性能，以及在酸性和过表达 H ₂ O _{2 的}肿瘤中 DOX 的pH/H ₂ O ₂双响应释放微环境，产生优异的化学光热治疗效果。PAA@PPyCOOH的降解机理被认为是吡咯-3-COOH单元与H ₂ O ₂之间的开环反应。更重要的是，纳米颗粒可以被肿瘤中过量的H ₂ O ₂特异性降解，并且降解产物被证实通过尿液和粪便排出体外。化学光热疗法的体内治疗评估表明，4T1 乳腺癌模型的肿瘤生长受到显着抑制，并且未检测到明显的副作用，从而表明其在临床应用中的巨大潜力。